Department of Neurology and Psychiatry, Sapienza University, Rome, Italy.
BMC Gastroenterol. 2011 Aug 26;11:94. doi: 10.1186/1471-230X-11-94.
Irritable bowel syndrome (IBS) and functional dyspepsia (FD) show considerable overlap and are both associated with psychiatric comorbidity. The present study aimed to investigate whether IBS patients with FD show higher levels of psychopathology than those without FD. As a preliminary analysis, it also evaluated the psychopathological differences, if any, between IBS patients featuring the two Rome III-defined FD subtypes, i.e. postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS).
Consecutive outpatients (n = 82, F = 67, mean age 41.6 ± 12.7 years) referred to our third level gastroenterological centre, matching the Rome III criteria for IBS and, if present, for concurrent FD, were recruited. They were asked to complete a 90-item self-rating questionnaire, the Symptom Checklist 90 Revised (SCL-90-R), in order to assess the psychological status. Comparisons between groups were carried out using the non-parametric Mann-Whitney U test.
Patients with IBS only were 56 (68.3%, F = 43, mean age 41.6 ± 13.3 years) and patients with both IBS and FD were 26 (31.7%, F = 24, mean age 41.8 ± 11.5 years), 17 of whom had PDS and 9 EPS. Patients with both IBS and FD scored significantly higher on the SCL-90-R GSI and on eight out of the nine subscales than patients with IBS only (P ranging from 0.000 to 0.03). No difference was found between IBS patients with PDS and IBS patients with EPS (P ranging from 0.07 to 0.97), but this result has to be considered provisional, given the small sample size of the two subgroups.
IBS-FD overlap is associated with an increased severity of psychopathological features. This finding suggests that a substantial subset of patients of a third level gastroenterological centre with both IBS and FD may benefit from psychological assessment and treatment.
肠易激综合征（IBS）和功能性消化不良（FD）有很大的重叠，两者都与精神共病有关。本研究旨在探讨 IBS 合并 FD 的患者是否比无 FD 的患者表现出更高水平的精神病理学。作为初步分析，它还评估了 IBS 患者中存在两种罗马 III 定义的 FD 亚型（餐后不适综合征[PDS]和上腹痛综合征[EPS]）之间的精神病理学差异。
连续门诊患者（n = 82，F = 67，平均年龄 41.6 ± 12.7 岁）被招募到我们的三级胃肠病中心，符合罗马 III 标准的 IBS 和，如果存在的话，同时符合 FD。他们被要求完成 90 项自评问卷，症状检查表 90 修订版（SCL-90-R），以评估心理状态。使用非参数 Mann-Whitney U 检验进行组间比较。
仅患有 IBS 的患者为 56 例（68.3%，F = 43，平均年龄 41.6 ± 13.3 岁），同时患有 IBS 和 FD 的患者为 26 例（31.7%，F = 24，平均年龄 41.8 ± 11.5 岁），其中 17 例为 PDS，9 例为 EPS。同时患有 IBS 和 FD 的患者在 SCL-90-R GSI 及九个子量表中的八个子量表上的得分明显高于仅患有 IBS 的患者（P 值范围从 0.000 到 0.03）。在 PDS 和 EPS 患者之间未发现差异（P 值范围从 0.07 到 0.97），但由于两个亚组的样本量较小，该结果必须被认为是暂定的。
IBS-FD 重叠与精神病理学特征的严重程度增加有关。这一发现表明，三级胃肠病中心的大量 IBS 和 FD 患者可能受益于心理评估和治疗。
