Department of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA.
Comput Biol Med. 2011 Oct;41(10):936-45. doi: 10.1016/j.compbiomed.2011.08.004. Epub 2011 Aug 27.
To determine the impact of mechanical heterogeneity on the distribution of regional flows and pressures in the injured lung, we developed an anatomic model of the canine lung comprised of an asymmetric branching airway network, which can be stored as binary tree data structure. The entire tree can be traversed using a recursive flow divider algorithm, allowing for efficient computation of acinar flow and pressure distributions in a mechanically heterogeneous lung. These distributions were found to be highly dependent on ventilation frequency and the heterogeneity of tissue elastances, reflecting the preferential distribution of ventilation to areas of lower regional impedance.
为了确定机械异质性对损伤肺中区域流量和压力分布的影响，我们开发了一个由非对称分支气道网络组成的犬肺解剖模型，该模型可以存储为二叉树数据结构。整个树可以使用递归流分配器算法进行遍历，从而可以有效地计算机械异质肺中的腺泡流量和压力分布。这些分布高度依赖于通气频率和组织弹性的异质性，反映了通气向区域阻抗较低的区域的优先分布。
