异三聚体 G 蛋白 G12 和 G13 调节 RhoGTP 酶的信号机制。
Signalling mechanisms of RhoGTPase regulation by the heterotrimeric G proteins G12 and G13.
机构信息
Laboratory of Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo 153-8904, Japan.
出版信息
J Biochem. 2011 Oct;150(4):357-69. doi: 10.1093/jb/mvr105. Epub 2011 Aug 26.
Abstract
G protein-mediated signal transduction can transduce signals from a large variety of extracellular stimuli into cells and is the most widely used mechanism for cell communication at the membrane. The RhoGTPase family has been well established as key regulators of cell growth, differentiation and cell shape changes. Among G protein-mediated signal transduction, G12/13-mediated signalling is one mechanism to regulate RhoGTPase activity in response to extracellular stimuli. The alpha subunits of G12 or G13 have been shown to interact with members of the RH domain containing guanine nucleotide exchange factors for Rho (RH-RhoGEF) family of proteins to directly connect G protein-mediated signalling and RhoGTPase signalling. The G12/13-RH-RhoGEF signalling mechanism is well conserved over species and is involved in critical steps for cell physiology and disease conditions, including embryonic development, oncogenesis and cancer metastasis. In this review, we will summarize current progress on this important signalling mechanism.
摘要
G 蛋白介导的信号转导可以将来自各种细胞外刺激的信号转导到细胞内，是细胞膜上细胞通讯最广泛使用的机制。RhoGTPase 家族已被确定为细胞生长、分化和细胞形状变化的关键调节因子。在 G 蛋白介导的信号转导中，G12/13 介导的信号转导是一种响应细胞外刺激调节 RhoGTPase 活性的机制。已经表明，G12 或 G13 的α亚基与包含 RH 结构域的鸟嘌呤核苷酸交换因子家族的 Rho（RH-RhoGEF）家族的成员相互作用，以直接连接 G 蛋白介导的信号转导和 RhoGTPase 信号转导。G12/13-RH-RhoGEF 信号转导机制在物种间高度保守，参与细胞生理学和疾病状态的关键步骤，包括胚胎发育、肿瘤发生和癌症转移。在这篇综述中，我们将总结这一重要信号转导机制的最新进展。
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