The Leeds Centre for Reproductive Medicine, Seacroft Hospital, Leeds LS146UH, UK.
Hum Reprod. 2011 Nov;26(11):2935-43. doi: 10.1093/humrep/der281. Epub 2011 Aug 26.
An increasing number of cancer patients can now hope to have a full and normal life due to significant improvements in treatment outcomes and survival rates. The application of cryobiology to store fertile gametes before sterilizing treatments has been a natural progression. Greater awareness has markedly increased the worldwide demand for long-term storage of sperm, and has prompted the UK Human Fertilization and Embryology Authority to extend the period of storage permitted by their regulations to 55 years. Other patients undergoing sterilizing chemotherapy and/or radiotherapy such as haemoglobinopathies requiring bone marrow transplantation and autoimmune disorders such as rheumatoid arthritis may further increase the indications for sperm storage. Most adult and adolescent patients and their relatives/spouses/parents/guardians value this service even though very few eventually use the sperm. There is an urgent need to develop national and international guidelines for the provision, organization, maintenance and management of the cryopreservation services.
由于治疗效果和存活率的显著提高，现在越来越多的癌症患者有望过上充实和正常的生活。在进行绝育治疗之前，应用低温生物学来储存可育配子是自然而然的发展。人们对长期储存精子的认识显著提高，这促使英国人类受精和胚胎管理局将其法规允许的储存期限延长至 55 年。其他接受绝育化疗和/或放疗的患者，如需要骨髓移植的血红蛋白病和类风湿性关节炎等自身免疫性疾病，可能会进一步增加精子储存的指征。大多数成年和青少年患者及其亲属/配偶/父母/监护人都重视这项服务，尽管很少有人最终使用精子。现在迫切需要制定国家和国际指南，以提供、组织、维护和管理冷冻保存服务。
