Sanchez V, Calvo J R, Goberna R
Department of Medical Biochemistry and Molecular Biology, School of Medicine, University of Sevilla, Spain.
Biosci Rep. 1990 Feb;10(1):87-91. doi: 10.1007/BF01116856.
Pancreastatin is a novel 49-amino acid peptide with a C-terminal glycine amide. The peptide was isolated from porcine pancreatic extracts and shows a structural similarity to chromogranin A. The effect of synthetic porcine pancreastatin on blood glucose levels and hepatic glycogen content was investigated in rats in vivo. Pancreastatin (300 pmol/kg) produced a time-dependent decrease in glycogen content of liver and a slight hyperglycemia. Basal plasma insulin and glucagon levels were not modified by pancreastatin. We suggest that pancreastatin could play a biological role in the glucose metabolism through a glycogenolytic effect.
胰抑制素是一种新型的49个氨基酸的肽，其C末端为甘氨酰胺。该肽是从猪胰腺提取物中分离出来的，与嗜铬粒蛋白A具有结构相似性。在大鼠体内研究了合成猪胰抑制素对血糖水平和肝糖原含量的影响。胰抑制素（300 pmol/kg）使肝脏糖原含量呈时间依赖性下降，并导致轻微的高血糖。胰抑制素对基础血浆胰岛素和胰高血糖素水平没有影响。我们认为胰抑制素可能通过糖原分解作用在葡萄糖代谢中发挥生物学作用。
