Department of Physics, Center for Theoretical Biological Physics, University of California, San Diego, La Jolla, CA 92093, USA.
Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15184-9. doi: 10.1073/pnas.1112034108. Epub 2011 Aug 29.
Spontaneous directed motion, a hallmark of cell biology, is unusual in classical statistical physics. Here we study, using both numerical and analytical methods, organized motion in models of the cytoskeleton in which constituents are driven by energy-consuming motors. Although systems driven by small-step motors are described by an effective temperature and are thus quiescent, at higher order in step size, both homogeneous and inhomogeneous, flowing and oscillating behavior emerges. Motors that respond with a negative susceptibility to imposed forces lead to an apparent negative-temperature system in which beautiful structures form resembling the asters seen in cell division.
自发性定向运动是细胞生物学的一个标志，在经典统计物理学中并不常见。在这里，我们使用数值和分析方法研究了细胞骨架模型中的组织运动，其中组成部分由耗能的马达驱动。尽管由小步长马达驱动的系统由有效温度描述，因此是静止的，但在更大的步长阶数下，无论是均匀的还是不均匀的，流动和振荡行为都会出现。对施加力表现出负敏感性的马达会导致一个表观的负温度系统，其中形成的美丽结构类似于细胞分裂中看到的星状体。
