Cimperman Joze, Maraspin Vera, Lotric-Furlan Stanka, Ruzić-Sabljić Eva, Avsic-Zupanc Tatjana, Strle Franc
University Medical Centre, Ljubljana, Slovenia.
Wien Klin Wochenschr. 2002 Jul 31;114(13-14):620-2.
The limited information on co-infection with Borrelia burgdorferi sensu lato and tick-borne encephalitis (TBE) virus was a stimulus for presentation of two patients with well-defined double infection of the central nervous system. TBE virus and B. burgdorferi sensu lato infections are searched for in all patients with lymphocytic meningitis and/or meningoencephalitis admitted to our department. During the last ten years we identified two patients who had ELISA IgM and IgG antibodies to TBE virus in serum and a positive PCR result for TBE virus in cerebrospinal fluid as well as B. burgdorferi sensu lato isolated from cerebrospinal fluid. Intrathecal production of borrelial antibodies was not proven in either of the two patients. These findings show that in patients with acute lymphocytic meningitis originating in regions endemic for Lyme borreliosis and TBE, the possibility of concomitant infection should be considered.
关于莱姆病疏螺旋体狭义种（Borrelia burgdorferi sensu lato）与蜱传脑炎（TBE）病毒合并感染的信息有限，这促使我们报告两例中枢神经系统明确的双重感染患者。我们对所有因淋巴细胞性脑膜炎和/或脑膜脑炎入住我科的患者进行了TBE病毒和莱姆病疏螺旋体狭义种感染的检测。在过去十年中，我们发现两名患者血清中TBE病毒的ELISA IgM和IgG抗体呈阳性，脑脊液中TBE病毒的PCR结果呈阳性，同时从脑脊液中分离出莱姆病疏螺旋体狭义种。两名患者均未证实有鞘内产生疏螺旋体抗体的情况。这些发现表明，在莱姆病和TBE流行地区发生急性淋巴细胞性脑膜炎的患者中，应考虑合并感染的可能性。
