Ptacek Radek, Kuzelova Hana, Stefano George B
Department of Psychiatry, Charles University, Prague, Czech Republic.
Neuro Endocrinol Lett. 2011;32(4):389-99.
Psychiatric genetics is a popular and much-discussed topic. Many candidate genes have been investigated in relation to psychiatric disorders and many connections have been found. The utilization of these investigations is currently at a theoretical level. Nevertheless, these findings of candidate genes will be important for further research and subsequent clinical use, for example in pharmacogenetics). Due to the rapidly growing number of empirical studies that provide profound analysis of different genes and their variants in different psychiatrical symptomatology, the field is highly divided, and providing a succinct overview is challenging. This article attempts to provide an up-to-date review of the most important and most discussed genes (mainly transporter and receptor genes) contributing to the etiology of psychiatric disorders.
精神遗传学是一个热门且备受讨论的话题。许多候选基因已针对精神障碍进行了研究，并发现了许多关联。目前这些研究的应用尚处于理论层面。然而，这些候选基因的发现对于进一步的研究及后续的临床应用（例如在药物遗传学方面）将具有重要意义。由于实证研究数量迅速增长，这些研究对不同精神症状学中的不同基因及其变体进行了深入分析，该领域高度分化，因此提供一个简洁的概述具有挑战性。本文试图对导致精神障碍病因的最重要且讨论最多的基因（主要是转运体和受体基因）进行最新综述。
