Layfield Lester J, Emerson Lyska, Crim Julia R, Randall Lor
Departments of Pathology.
Clin Med Pathol. 2008;1:55-9. doi: 10.4137/cpath.s582. Epub 2008 Mar 18.
Cytokeratin expression has been documented in a variety of sarcomas including synovial sarcomas, epithelioid sarcomas, Ewing's sarcomas and, rarely, osteosarcomas. In osteosarcomas immunohistochemically shown to expression cytokeratins, a component of epithelioid cells is generally present. These epithelioid cytokeratin positive cells raise the possibility of metastatic disease with prognostic and therapeutic implications differing from primary osteosarcoma. The cytokeratin-expressing cells of the cases reported in the literature have not shown definitive squamous differentiation with keratin pearl formation. We report a case of osteosarcoma in which islands of malignant squamous cells were present showing keratin pearl formation and expression of cytokeratins.
细胞角蛋白表达已在多种肉瘤中得到证实，包括滑膜肉瘤、上皮样肉瘤、尤因肉瘤，骨肉瘤中也有罕见表达。在免疫组化显示表达细胞角蛋白的骨肉瘤中，通常存在上皮样细胞成分。这些上皮样细胞角蛋白阳性细胞提示可能存在转移性疾病，其预后和治疗意义与原发性骨肉瘤不同。文献报道病例中表达细胞角蛋白的细胞未显示出明确的鳞状分化及角质珠形成。我们报告一例骨肉瘤病例，其中存在恶性鳞状细胞岛，显示角质珠形成及细胞角蛋白表达。
