Nogueira Paulo Cesar Koch, Feltran Luciana de Santis, Camargo Maria Fernanda, Leão Eliseth Ribeiro, Benninghoven Jennifer Rcs, Gonçalves Natália Z, Pereira Luiz A, Sesso Ricardo C
Service of Pediatric Nephrology, Hospital Samaritano de São Paulo, São Paulo, SP, Brazil.
Rev Assoc Med Bras (1992). 2011 Jul-Aug;57(4):436-41.
To estimate the prevalence of pediatric end-stage renal disease and evaluate demographics and renal disease characteristics in state of São Paulo over the year 2008.
Observational, descriptive, and cross-sectional study based on a population sample with subjects < 18 years. The data collecting assumed three forms: 1. A questionnaire for dialysis units; 2. Search in the Transplant Center to determine the number and characteristics of patients who had been in a transplant waiting list over the study period; 3. Search in the database of patients registered at the Latin American Collaborative Registry of Pediatric Kidney Transplantation.
Data from 301 patients aged 9.0 ± 5.8, including 140 girls (46.5%), resulting in an estimate prevalence of 23.4 cases per million age-related population (pmarp). The age group most frequently found was 10 to 15 years (32.2%), and urinary tract malformation was the most usual known etiology (24.9%). Most children underwent kidney transplantation (62.1%) and among subjects on dialysis, hemodialysis was predominant (71.2%). The Sistema Único de Saúde - Unified National Health System - (SUS) provided the financial support for treatments.
The prevalence of 23.4 cases pmarp found by the authors is lower than that reported in Western world. We believe data were underestimated in the present study, as few dialysis units returned the completed questionnaire. This potential bias does not invalidate the exploratory character of results. Further mechanisms for retrospective and earlier data collecting on pediatric chronic renal disease (CRD) are needed so that the burden of this serious health condition can be appropriately sized up.
评估2008年圣保罗州儿童终末期肾病的患病率，并分析其人口统计学特征及肾病特点。
基于18岁以下人群样本开展观察性、描述性横断面研究。数据收集采用三种方式：1. 向透析单位发放问卷；2. 在移植中心查询，以确定研究期间进入移植等待名单的患者数量及特征；3. 检索拉丁美洲儿童肾移植协作登记处登记的患者数据库。
共纳入301例患者，年龄9.0±5.8岁，其中女孩140例（46.5%），估算患病率为每百万年龄相关人口23.4例（pmarp）。最常见的年龄组为10至15岁（32.2%），已知最常见的病因是尿路畸形（24.9%）。大多数儿童接受了肾移植（62.1%），在透析患者中，血液透析占主导（71.2%）。巴西统一卫生系统（SUS）为治疗提供了资金支持。
作者发现的23.4例pmarp的患病率低于西方世界报道的患病率。我们认为本研究中的数据被低估了，因为很少有透析单位返回完整的问卷。这种潜在偏差并不影响结果的探索性。需要进一步建立回顾性和早期收集儿童慢性肾病（CRD）数据的机制，以便能够恰当地评估这种严重健康状况的负担。
