Charveron M, Calvo M, Gall Y
Pôle Recherche et Evaluation, Castanet-Tolosan, France.
Cell Biol Toxicol. 1995 Aug;11(3-4):161-5. doi: 10.1007/BF00756518.
Heat-shock proteins (HSPs), or so-called 'stress proteins' may play an important role in cutaneous pathophysiology. HSPs are a group of highly conserved molecules that are expressed by all cells when subjected to heat or other forms of physical or chemical stress. The physiological roles of stress proteins are varied and are important in stress and nonstress conditions. They bind to other cellular proteins and participate in protein folding pathways during stress and also during the synthesis of new polypeptides. HSPs are also essential for thermotolerance and for prevention and repair of damage caused in DNA after ultraviolet exposure. Although HSPs are expressed in the skin in both epidermis and dermis, HSPs may influence many other cellular processes in the inflammatory and immune skin response. Many authors have speculated on a link between HSPs and human skin disease characterized by inflammation and proliferation.
热休克蛋白（HSPs），即所谓的“应激蛋白”，可能在皮肤病理生理学中发挥重要作用。热休克蛋白是一组高度保守的分子，当所有细胞受到热或其他形式的物理或化学应激时都会表达。应激蛋白的生理作用多种多样，在应激和非应激条件下都很重要。它们与其他细胞蛋白结合，并在应激期间以及新多肽合成期间参与蛋白质折叠途径。热休克蛋白对于耐热性以及紫外线照射后DNA损伤的预防和修复也至关重要。尽管热休克蛋白在表皮和真皮的皮肤中均有表达，但它们可能会影响炎症性和免疫性皮肤反应中的许多其他细胞过程。许多作者推测热休克蛋白与以炎症和增殖为特征的人类皮肤疾病之间存在联系。
