Departmen tof Pathology and Laboratory Medicine, University of Florida, Jacksonville 32209, USA.
Arch Pathol Lab Med. 2011 Sep;135(9):1097-100. doi: 10.5858/2010-0334-RSR1.1.
Choriocarcinomatous differentiation has been described in tumors arising from many organs including lung, rectum, colon, stomach, bladder, and rarely breast. Mammary carcinoma with choriocarcinomatous features is a rare variant of breast metaplastic carcinoma characterized by malignant cells morphologically resembling choriocarcinoma cells in which reactivity with human placental lactogen and human chorionic gonadotropin can be demonstrated by immunohistochemistry. The characteristic syncytiotrophoblast-like giant cells seen in these neoplasms are more commonly associated with moderately to poorly differentiated carcinomas with or without a clear-cut mesenchymal component. Most of the reported cases have behaved very aggressively. The reason for this poor prognosis remains unclear. Because of the small number of cases, special treatment protocols have not been developed and these patients are treated surgically and with the standard chemotherapeutic agents available for other types of carcinoma of the breast. Pathologically, these tumors must be distinguished from metastatic choriocarcinoma to the breast.
绒毛膜癌分化已在许多器官的肿瘤中描述，包括肺、直肠、结肠、胃、膀胱，很少见的还有乳房。具有绒毛膜癌特征的乳腺癌是一种罕见的乳腺间变性癌的变体，其特征是恶性细胞形态上类似于绒毛膜癌细胞，免疫组织化学可显示其对人胎盘催乳素和人绒毛膜促性腺激素的反应性。在这些肿瘤中可见的特征性合体滋养层样巨细胞更常见于中至低分化癌，伴有或不伴有明确的间充质成分。大多数报道的病例表现出很强的侵袭性。这种不良预后的原因尚不清楚。由于病例数量较少，尚未制定特殊的治疗方案，这些患者接受手术治疗和其他类型乳腺癌标准的化疗药物治疗。从病理上看，这些肿瘤必须与转移到乳房的绒毛膜癌区分开来。
