Xu Jingchun, Xu Yi, Xu Cheng, Wang Cong
Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Front Oncol. 2023 Mar 8;13:984425. doi: 10.3389/fonc.2023.984425. eCollection 2023.
Here we present a rare case of breast cancer with both invasive ductal carcinoma and choriocarcinoma components in a 55-year-old woman. Firstly, the serum human chorionic gonadotropin level showed 15.9mIU/ml preoperatively. And adequate immunohistochemical tests were performed on the specimen. Secondly, High-throughput sequencing was performed to detect the molecular characteristics of the two components, respectively. Then, DNA short tandem repeat (STR) analysis confirmed the homology of the two components, indicating the somatic origin of choriocarcinoma components. Finally, the clinical course and pathological characteristics of the case were reviewed and a literature search for other cases was performed.
在此，我们报告一例罕见的55岁女性乳腺癌病例，其兼具浸润性导管癌和绒毛膜癌成分。首先，术前血清人绒毛膜促性腺激素水平显示为15.9mIU/ml。并对标本进行了充分的免疫组化检测。其次，进行高通量测序以分别检测两种成分的分子特征。然后，DNA短串联重复序列（STR）分析证实了两种成分的同源性，表明绒毛膜癌成分起源于体细胞。最后，回顾了该病例的临床病程和病理特征，并检索文献查找其他病例。
