Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Nat Rev Drug Discov. 2011 Aug 31;10(9):671-84. doi: 10.1038/nrd3504.
Genetic events in cancer activate signalling pathways that alter cell metabolism. Clinical evidence has linked cell metabolism with cancer outcomes. Together, these observations have raised interest in targeting metabolic enzymes for cancer therapy, but they have also raised concerns that these therapies would have unacceptable effects on normal cells. However, some of the first cancer therapies that were developed target the specific metabolic needs of cancer cells and remain effective agents in the clinic today. Research into how changes in cell metabolism promote tumour growth has accelerated in recent years. This has refocused efforts to target metabolic dependencies of cancer cells as a selective anticancer strategy.
癌症中的遗传事件激活了改变细胞代谢的信号通路。临床证据将细胞代谢与癌症结果联系起来。这些观察结果共同引起了人们对针对代谢酶进行癌症治疗的兴趣，但也引起了人们的担忧，即这些疗法可能对正常细胞产生不可接受的影响。然而，一些最初开发的癌症疗法针对癌细胞的特定代谢需求，并且至今仍是临床上有效的药物。近年来，关于细胞代谢变化如何促进肿瘤生长的研究进展迅速。这重新将努力集中在靶向癌细胞的代谢依赖性作为一种选择性抗癌策略上。
