Sjöström H, Norén O, Krasilnikoff P A, Gudmand-Høyer E
Clin Chim Acta. 1981 Jan 8;109(1):53-8. doi: 10.1016/0009-8981(81)90136-4.
The activities of microvillus aminopeptidase (microsomal, EC 3.4.11.2), dipeptidyl peptidase IV (EC 3.4.14.-), glycyl-leucine dipeptidase (EC 3.4.13.11), proline dipeptidase (EC 3.4.13.9), sucrase (EC 3.2.1.48) and gamma-glutamyl transpeptidase (EC 2.3.2.2) were measured in peroral intestinal biopsies taken from patients with coeliac disease in the acute phase and in remission. A comparison with the amounts of corresponding activities from a reference group showed that all the measured activities were significantly decreased in the acute phase of the disease. In patients in remission only microvillus aminopeptidase and dipeptidyl dipeptidase IV displayed a substantial depression as compared to the reference group. It is suggested that a primary mucosal digestion defect will result in lack of substrate for other intestinal enzymes. This is a situation comparable to starvation and may explain the variation in the grade of restitution for the different enzymes.
对处于急性期和缓解期的乳糜泻患者进行经口肠道活检，测定其中微绒毛氨肽酶（微粒体，EC 3.4.11.2）、二肽基肽酶IV（EC 3.4.14.-）、甘氨酰 - 亮氨酸二肽酶（EC 3.4.13.11）、脯氨酸二肽酶（EC 3.4.13.9）、蔗糖酶（EC 3.2.1.48）和γ-谷氨酰转肽酶（EC 2.3.2.2）的活性。与参考组相应活性水平进行比较发现，疾病急性期所有测定的活性均显著降低。与参考组相比，缓解期患者仅微绒毛氨肽酶和二肽基肽酶IV表现出明显降低。提示原发性黏膜消化缺陷会导致其他肠道酶缺乏底物。这种情况与饥饿类似，可能解释了不同酶恢复程度的差异。
