连二亚硫酸钠还原钴胺素。形成六配位钴胺素(II)配合物的证据。
Cobalamin reduction by dithionite. Evidence for the formation of a six-coordinate cobalamin(II) complex.
机构信息
State University of Chemistry and Technology, Ivanovo, Russia.
出版信息
Dalton Trans. 2011 Oct 14;40(38):9831-4. doi: 10.1039/c1dt10219b. Epub 2011 Aug 30.
PMID:21879074
Abstract
Evidence for the formation of a unique, six-coordinate cobalamin(II) complex with the anion-radical SO(2)(-) during the reduction of aquacobalamin(III) by sodium dithionite, was obtained from spectrophotometric and EPR measurements. The pK(a) value of the weakly coordinated dimethylbenzimidazole group was found to be 4.8 ± 0.1 at 25 °C.
摘要
通过分光光度法和电子顺磁共振（EPR）测量，得到了在连二亚硫酸钠还原水合钴胺素（III）的过程中形成独特的六配位钴胺素（II）配合物与阴离子自由基 SO(2)(-)的证据。在 25°C 下，弱配位的二甲基苯并咪唑基团的 pK(a) 值被发现为 4.8±0.1。
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