[Ru(bpy)2(5-氰尿嘧啶)2]2+ 作为一种潜在的光激活双重作用治疗剂。
[Ru(bpy)2(5-cyanouracil)2]2+ as a potential light-activated dual-action therapeutic agent.
机构信息
Department of Chemistry, The Ohio State University, Columbus, Ohio 43210, United States.
出版信息
Inorg Chem. 2011 Oct 3;50(19):9213-5. doi: 10.1021/ic201615u. Epub 2011 Aug 31.
Abstract
The cation cis-Ru(bpy)(2)(5CNU)(2) (bpy = 2,2'-bipyridine; 5CNU = 5-cyanouracil) was synthesized and investigated for use as a potential light-activated dual-action therapeutic agent. The complex undergoes efficient photoinduced 5CNU ligand exchange for solvent water molecules, thus simultaneously releasing biologically active 5CNU and generating Ru(bpy)(2)(H(2)O)(2). The latter binds covalently to ds-DNA, such that photolysis results in the generation of 3 equiv of potential therapeutic agents from a single molecule.
摘要
顺式-Ru(bpy)(2)(5CNU)(2)（bpy = 2,2'-联吡啶；5CNU = 5-氰尿嘧啶）阳离子被合成并研究用作潜在的光激活双重作用治疗剂。该配合物经历高效光诱导 5CNU 配体交换为溶剂水分子，从而同时释放生物活性 5CNU 并生成Ru(bpy)(2)(H(2)O)(2)。后者与 ds-DNA 共价结合，使得光解导致从单个分子生成 3 当量的潜在治疗剂。
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