来自狭基线纹香茶菜的抗乙型肝炎病毒及细胞毒性二萜类化合物。
Anti-hepatitis B virus and cytotoxic diterpenoids from Isodon lophanthoides var. gerardianus.
作者信息
Yang Li-bin, Li Lin, Huang Sheng-xiong, Pu Jian-xin, Zhao Yong, Ma Yun-bao, Chen Ji-jun, Leng Chun-hong, Tao Zheng-ming, Sun Han-dong
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences.
出版信息
Chem Pharm Bull (Tokyo). 2011;59(9):1102-5. doi: 10.1248/cpb.59.1102.
Four new diterpenoides, isolophanthins A-D (1-4) together with seven known abietane diterpenoides (5-11), have been isolated from Isodon lophanthoides var. gerardianus. The new diterpenoides were elucidated by spectroscopic analysis. Some of them showed significant activities against HBsAg and HBeAg of hepatitis B virus in Hep G 2.2.15 cells, as well as the human tumor cell lines, HL-60, A-549, MOLT-4, and BEL-7402.
从线纹香茶菜中分离得到了4个新的二萜类化合物，异线纹香茶菜素A-D（1-4）以及7个已知的枞酸型二萜类化合物（5-11）。通过光谱分析对新的二萜类化合物进行了结构鉴定。其中一些化合物对Hep G 2.2.15细胞中的乙肝病毒表面抗原（HBsAg）和乙肝病毒e抗原（HBeAg）以及人肿瘤细胞系HL-60、A-549、MOLT-4和BEL-7402显示出显著活性。
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