Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Japan.
J Pharmacol Sci. 2011;117(2):71-6. doi: 10.1254/jphs.11r07cp. Epub 2011 Sep 1.
Interplay between genetic and environmental factors plays a key role in psychiatric disorders, as well as other brain diseases, cancer, and metabolic syndrome. In accordance with epidemiological findings, animal studies have pointed out the importance of a variety of environmental factors, such as viral infection during pregnancy or infancy, early parental loss or separation, and physical or sexual abuse in early life, in the etiology of psychiatric disorders. Conversely, positive effects of environmental factors against the pathogenesis of psychiatric disorders are also demonstrated, in which most of the animals are exposed to an "enriched environment". This review summarizes recent progress of research in this field focusing on the preventive effects of an "enriched environment" against the expression of behavioral abnormalities in rodent models of psychiatric disorders.
遗传和环境因素的相互作用在精神障碍以及其他脑部疾病、癌症和代谢综合征中起着关键作用。根据流行病学研究结果，动物研究指出了各种环境因素的重要性，如妊娠或婴儿期的病毒感染、早年父母丧失或分离，以及生命早期的身体或性虐待，这些都与精神障碍的病因有关。相反，环境因素对精神障碍发病机制的积极影响也得到了证明，其中大多数动物都暴露在“丰富环境”中。本综述总结了这一领域的最新研究进展，重点介绍了“丰富环境”对精神障碍啮齿动物模型行为异常表达的预防作用。
