Ogata-Suetsugu Saiko, Maeyama Takashige, Takeshita Masafumi, Hamada Naoki, Takayama Koichi, Inoue Hiromasa, Nakanishi Yoichi
Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Ann Thorac Cardiovasc Surg. 2011;17(6):591-4. doi: 10.5761/atcs.cr.10.01651. Epub 2011 Aug 17.
We report a case of 77-year-old woman suffering from breathlessness on exertion and dry cough. Chest computed tomography (CT) showed diffuse ground-glass shadows. A video-assisted thoracoscopic lung biopsy resulted in the diagnosis of diffuse large B-cell lymphoma (DLBCL). Gene rearrangement analysis using polymerase chain reaction (PCR) technique was performed on the cells in bronchoalveolar lavage (BAL) fluid, and showed the clonality of the immunoglobulin heavy chain (IgH) gene, supporting the diagnosis. DLBCL should be considered in the differential diagnosis of diffuse ground-glass shadows in the chest CT, and gene rearrangement analysis may have an impact on the diagnosis of pulmonary DLBCL.
我们报告一例77岁女性，有劳力性呼吸困难和干咳症状。胸部计算机断层扫描（CT）显示弥漫性磨玻璃影。电视辅助胸腔镜肺活检确诊为弥漫性大B细胞淋巴瘤（DLBCL）。采用聚合酶链反应（PCR）技术对支气管肺泡灌洗（BAL）液中的细胞进行基因重排分析，结果显示免疫球蛋白重链（IgH）基因具有克隆性，支持该诊断。在胸部CT弥漫性磨玻璃影的鉴别诊断中应考虑DLBCL，基因重排分析可能对肺DLBCL的诊断有影响。
