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疾病中的细胞死亡:2010 年以后。

Cell death in disease: from 2010 onwards.

机构信息

Toxicology Unit, Medical Research Council, Leicester University, Leicester LE1 9HN, UK.

出版信息

Cell Death Dis. 2011 Sep 1;2(9):e202. doi: 10.1038/cddis.2011.89.

DOI:10.1038/cddis.2011.89
PMID:21881604
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3186907/
Abstract

The strong interest in cell death, and the shift in emphasis from basic mechanisms to translational aspects fostered the launch last year of the new sister journal of Cell Death and Differentiation, named Cell Death and Disease, to reflect its stronger focus towards clinical applications. Here, we review that first year of activity, which reflects an enthusiastic response by the scientific community. On the basis of this, we now launch two novel initiatives, the start of a new section dedicated to cancer metabolism and the opening of a new editorial office in Shanghai.

摘要

人们对细胞死亡有着浓厚的兴趣,研究重点也从基础机制转向了转化应用,这种趋势促进了 Cell Death and Differentiation 的姊妹期刊——Cell Death and Disease 的诞生,以反映其对临床应用的更强烈关注。在这里,我们回顾了创刊的第一年,这反映了科学界的热情响应。在此基础上,我们现在推出了两项新举措,开设了一个专门研究癌症代谢的新版块,并在上海开设了一个新的编辑部。

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本文引用的文献

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IGF1 activates cell cycle arrest following irradiation by reducing binding of ΔNp63 to the p21 promoter.IGF1 通过减少 ΔNp63 与 p21 启动子的结合来激活细胞周期阻滞,从而减少细胞周期阻滞。
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The p53 family: guardians of maternal reproduction.p53 家族:母性生殖的守护者。
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TGF-β induces TIAF1 self-aggregation via type II receptor-independent signaling that leads to generation of amyloid β plaques in Alzheimer's disease.
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为社群而死:细菌程序性细胞死亡概述。
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Role of apoptosis in disease.细胞凋亡在疾病中的作用。
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Cancer metabolism: current perspectives and future directions.癌症代谢:当前的观点和未来的方向。
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TGF-β 通过 II 型受体非依赖信号诱导 TIAF1 自聚集,从而导致阿尔茨海默病中淀粉样 β 斑块的产生。
Cell Death Dis. 2010 Dec 23;1(12):e110. doi: 10.1038/cddis.2010.83.
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p73 deficiency results in impaired self renewal and premature neuronal differentiation of mouse neural progenitors independently of p53.p73 缺失导致小鼠神经祖细胞自我更新受损和过早神经元分化,与 p53 无关。
Cell Death Dis. 2010 Dec 16;1(12):e109. doi: 10.1038/cddis.2010.87.
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Obatoclax induces Atg7-dependent autophagy independent of beclin-1 and BAX/BAK.奥巴克拉克斯诱导 Atg7 依赖性自噬,不依赖于 beclin-1 和 BAX/BAK。
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Downregulation of miR-205 and miR-31 confers resistance to chemotherapy-induced apoptosis in prostate cancer cells.miR-205 和 miR-31 的下调使前列腺癌细胞对化疗诱导的细胞凋亡产生抗性。
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