Tucci Paola
Medical Research Council, Toxicology Unit, Leicester University, Leicester LE1 9HN, UK.
Aging (Albany NY). 2012 Aug;4(8):525-34. doi: 10.18632/aging.100481.
Caloric restriction, that is limiting food intake, is recognized in mammals as the best characterized and most reproducible strategy for extending lifespan, retarding physiological aging and delaying the onset of age-associated diseases. The aim of this mini review is to argue that p53 is the connection in the abilities of both the Sirt-1 pathway and the TOR pathway to impact on longevity of cells and organisms. This novel, lifespan regulating function of p53 may be evolutionarily more ancient than its relatively recent role in apoptosis and tumour suppression, and is likely to provide many new insights into lifespan modulation.
热量限制，即限制食物摄入量，在哺乳动物中被认为是延长寿命、延缓生理衰老和推迟与年龄相关疾病发生的最具特征且最可重复的策略。本综述的目的是论证p53是Sirt-1途径和TOR途径影响细胞和生物体寿命能力之间的联系。p53这种新的寿命调节功能在进化上可能比其在凋亡和肿瘤抑制方面相对较新的作用更为古老，并且可能为寿命调节提供许多新的见解。
