Department of Psychiatry, University of Florida, Gainesville, FL, USA.
J Neurodev Disord. 2011 Dec;3(4):316-24. doi: 10.1007/s11689-011-9094-3. Epub 2011 Sep 1.
Restricted and repetitive behavior (RRB) is a group of heterogeneous maladaptive behaviors. RRB is one of the key diagnostic features of autism spectrum disorders (ASDs) and also commonly observed in Prader-Willi syndrome (PWS). In this study, we assessed RRB using the Repetitive Behavior Scale-Revised (RBS-R) in two ASD samples (University of Illinois at Chicago [UIC] and University of Florida [UF]) and one PWS sample. We compared the RBS-R item endorsements across three ASD cohorts (UIC, UF and an ASD sample from Lam, The Repetitive Behavior Scale-Revised: independent validation and the effect of subject variables, PhD thesis, 2004), and a PWS sample. We also compared the mean RBS-R subscale/sum scores across the UIC, UF and PWS samples; across the combined ASD (UIC + UF), PWS-deletion and PWS-disomy groups; and across the combined ASD sample, PWS subgroup with a Social Communication Questionnaire (SCQ) score ≥15, and PWS subgroup with a SCQ score <15. Despite the highly heterogeneous nature, the three ASD samples (UIC, UF and Lam's) showed a similar pattern of the RBS-R endorsements, and the mean RBS-R scores were not different between the UIC and UF samples. However, higher RRB was noted in the ASD sample compared with the PWS sample, as well as in the PWS subgroup with a SCQ score ≥15 compared with the PWS subgroup with a SCQ score <15. Study limitations include a small sample size, a wide age range of our participants, and not controlling for potential covariates. A future replication study using a larger sample and further investigation into the genetic bases of overlapping ASD and RRB phenomenology are needed, given the higher RRB in the PWS subgroup with a SCQ score ≥15.
受限和重复行为（RRB）是一组异质的适应不良行为。RRB 是自闭症谱系障碍（ASD）的关键诊断特征之一，也常见于普拉德-威利综合征（PWS）中。在这项研究中，我们使用修订后的重复行为量表（RBS-R）在两个 ASD 样本（伊利诺伊大学芝加哥分校[UIC]和佛罗里达大学[UF]）和一个 PWS 样本中评估了 RRB。我们比较了三个 ASD 队列（UIC、UF 和 Lam 的 ASD 样本，重复行为量表修订版：独立验证和受试者变量的影响，博士论文，2004 年）和一个 PWS 样本中的 RBS-R 项目认可。我们还比较了 UIC、UF 和 PWS 样本之间的 RBS-R 子量表/总分平均值；UIC、UF 和 PWS 样本之间的合并 ASD（UIC+UF）、PWS 缺失和 PWS 同型合子组之间；以及在合并的 ASD 样本中，SCQ 评分≥15 的 PWS 亚组和 SCQ 评分<15 的 PWS 亚组之间。尽管具有高度的异质性，但三个 ASD 样本（UIC、UF 和 Lam 的）表现出相似的 RBS-R 认可模式，UIC 和 UF 样本之间的 RBS-R 评分没有差异。然而，与 PWS 样本相比，ASD 样本中的 RRB 更高，与 SCQ 评分≥15 的 PWS 亚组相比，与 SCQ 评分<15 的 PWS 亚组中的 RRB 更高。研究局限性包括样本量小、参与者年龄范围广，以及未控制潜在协变量。鉴于 SCQ 评分≥15 的 PWS 亚组中 RRB 较高，需要进行更大样本的未来复制研究，并进一步研究重叠的 ASD 和 RRB 现象学的遗传基础。
