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三种筛查工具在孤独症谱系障碍识别中的效能

Efficacy of three screening instruments in the identification of autistic-spectrum disorders.

作者信息

Charman Tony, Baird Gillian, Simonoff Emily, Loucas Tom, Chandler Susie, Meldrum David, Pickles Andrew

机构信息

Behavioural and Brain Sciences Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.

出版信息

Br J Psychiatry. 2007 Dec;191:554-9. doi: 10.1192/bjp.bp.107.040196.

Abstract

BACKGROUND

Screening instruments for autistic-spectrum disorders have not been compared in the same sample.

AIMS

To compare the Social Communication Questionnaire (SCQ), the Social Responsiveness Scale (SRS) and the Children's Communication Checklist (CCC).

METHOD

Screen and diagnostic assessments on 119 children between 9 and 13 years of age with special educational needs with and without autistic-spectrum disorders were weighted to estimate screen characteristics for a realistic target population.

RESULTS

The SCQ performed best (area under receiver operating characteristic curve (AUC)=0.90; sensitivity 0.86; specificity 0.78). The SRS had a lower AUC (0.77) with high sensitivity (0.78) and moderate specificity (0.67). The CCC had a high sensitivity but lower specificity (AUC=0.79; sensitivity 0.93; specificity 0.46). The AUC of the SRS and CCC was lower for children with IQ < 70. Behaviour problems reduced specificity for all three instruments.

CONCLUSIONS

The SCQ, SRS and CCC showed strong to moderate ability to identify autistic-spectrum disorder in this at-risk sample of school-age children with special educational needs.

摘要

背景

尚未在同一样本中对自闭症谱系障碍筛查工具进行比较。

目的

比较社会交往问卷(SCQ)、社会反应量表(SRS)和儿童交流检查表(CCC)。

方法

对119名9至13岁有特殊教育需求、有或无自闭症谱系障碍的儿童进行筛查和诊断评估,并进行加权,以估计现实目标人群的筛查特征。

结果

SCQ表现最佳(受试者工作特征曲线下面积(AUC)=0.90;敏感性0.86;特异性0.78)。SRS的AUC较低(0.77),敏感性高(0.78),特异性中等(0.67)。CCC敏感性高但特异性较低(AUC=0.79;敏感性0.93;特异性0.46)。智商<70的儿童中,SRS和CCC的AUC较低。行为问题降低了所有三种工具的特异性。

结论

在这个有特殊教育需求的学龄高危儿童样本中,SCQ、SRS和CCC显示出较强至中等的识别自闭症谱系障碍的能力。

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