Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, PR China.
J Am Chem Soc. 2011 Oct 5;133(39):15268-71. doi: 10.1021/ja2056159. Epub 2011 Sep 8.
α-Diazoesters were discovered to be good electrophiles in a catalytic asymmetric α-functionalization of ketones for the first time. This reaction also provided a direct and efficient method for C-N bond formation with excellent yields (up to 98%) and enantioselectivities (up to 99% ee) under mild conditions. The application of the electrophilicity of α-diazoesters opens up a novel way to access the diversity of diazo chemistry.
α-重氮酯首次被发现是酮的催化不对称α-官能化反应中的一种良好的亲电试剂。该反应还提供了一种在温和条件下直接高效地形成 C-N 键的方法，产率高（高达 98%），对映选择性好（高达 99%ee）。α-重氮酯的亲电性的应用为进入重氮化学的多样性开辟了一条新途径。
