Service de Bactériologie-Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine et Université Paris-Sud, K. Bicêtre, France.
Clin Microbiol Infect. 2011 Oct;17(10):1524-8. doi: 10.1111/j.1469-0691.2011.03622.x. Epub 2011 Aug 29.
Thirteen carbapenem-resistant Acinetobacter baumannii isolates, collected in Romania during 2009-2010, were investigated to identify the mechanism(s) responsible for carbapenem resistance. Genotyping was performed by pulsed-field gel electrophoresis, multiplex PCR sequence typing and multilocus sequence typing. Eleven non-clonally related isolates harboured the bla(OXA-23) gene on their chromosome within a Tn2008 transposon structure. The two remaining isolates harboured a bla(OXA-58) gene that was either plasmid or chromosome borne. Two isolates co-expressed OXA-23 together with the extended-spectrum β-lactamase PER-1. This study constitutes the first report of OXA-58 and OXA-23-producing A. baumannii isolates in Romania.
2009-2010 年期间，罗马尼亚采集了 13 株耐碳青霉烯鲍曼不动杆菌分离株，对其进行研究以确定导致碳青霉烯类耐药的机制。通过脉冲场凝胶电泳、多重 PCR 序列分型和多位点序列分型进行基因分型。11 株非克隆相关的分离株在 Tn2008 转座子结构内的染色体上携带 bla(OXA-23)基因。其余两株分离株携带 bla(OXA-58)基因，该基因位于质粒或染色体上。两株分离株同时表达 OXA-23 和广谱β-内酰胺酶 PER-1。本研究首次报道了罗马尼亚产 OXA-58 和 OXA-23 的鲍曼不动杆菌分离株。
