Department of Community Medicine, UConn Health Center, Farmington, Connecticut, USA.
Cancer Sci. 2011 Dec;102(12):2236-40. doi: 10.1111/j.1349-7006.2011.02080.x. Epub 2011 Sep 27.
Iron can be a potent pro-oxidant and, on this basis, elevated body iron may increase the risk of cancer. Although epidemiological evidence is mixed, there is overall support for this possibility. In addition, because of this same oxidative capacity, body iron levels may alter radiation sensitivity. In the present study, a nested case-control study of breast cancer was conducted in Japanese atomic bomb survivors. Stored serum samples from the Adult Health Study cohort were assayed for ferritin levels and joint statistical analyses were conducted of ferritin and radiation dose on the risk of breast cancer. Serum ferritin is the best feasible indicator of body iron levels in otherwise healthy people. A total of 107 cases and 212 controls were available for analysis. The relative risk (RR) of breast cancer for a 1 log unit increase in ferritin was 1.4 (95% confidence interval 1.1-1.8). This translates to an RR of 1.64 comparing high and low values of the interquartile range among controls (58 and 13.2 ng/mL, respectively). The results support the hypothesis that elevated body iron stores increase the risk of breast cancer. However, the study was inconclusive regarding the question of whether body iron alters radiation-induced breast cancer risk.
铁可以是一种有效的促氧化剂，基于此，体内铁含量升高可能会增加癌症的风险。尽管流行病学证据存在分歧，但总体上支持这种可能性。此外，由于这种相同的氧化能力，体内铁水平可能会改变辐射敏感性。在本研究中，对日本原子弹幸存者进行了乳腺癌的巢式病例对照研究。对来自成人健康研究队列的储存血清样本进行了铁蛋白水平检测，并对铁蛋白和辐射剂量与乳腺癌风险进行了联合统计分析。血清铁蛋白是其他健康人群中铁水平的最佳可行指标。共有 107 例病例和 212 例对照可用于分析。铁蛋白每增加 1 个对数单位，乳腺癌的相对风险 (RR) 为 1.4（95%置信区间 1.1-1.8）。这相当于比较对照组中四分位间距的高低值（分别为 58 和 13.2ng/ml）的 RR 为 1.64。结果支持体内铁储存升高会增加乳腺癌风险的假设。然而，关于体内铁是否会改变辐射引起的乳腺癌风险的问题，该研究尚无定论。
