Imperial College Healthcare NHS Trust, Department of Haematology & WHO Collaboration Centre for Haematology Technology, London, UK.
Int J Lab Hematol. 2012 Feb;34(1):91-7. doi: 10.1111/j.1751-553X.2011.01365.x. Epub 2011 Aug 24.
The utility of the full blood count (FBC) is vast with each parameter serving as a tool to aid diagnosis and monitor disease progression. However, the effectiveness of the test is hampered because of increased workload and lack of interpretation. In the effort to redress this issue, the combined use of the white blood cell count (WBC) and haemoglobin in predicting the normality of the FBC is evaluated.
FBC data were collated from 2191 patients and classified into two groups depending on whether the WBC and the haemoglobin were within the reference range. Blood films were examined on the abnormal FBC samples in each group and graded on morphology.
The FBC was normal in 89.6% of cases in the presence of a normal WBC and haemoglobin with subtle abnormalities in the remainder; 1+ grading of abnormal morphology in 93%. However, when the WBC and/or haemoglobin was abnormal, the remaining FBC was significantly abnormal (P < 0.05) and the corresponding blood films were grossly abnormal; 2+/3+ grading in 96% of cases.
We concluded that in the presence of a normal WBC and haemoglobin, the FBC is normal in almost all cases and measuring these two parameters could be used as an effective screen to predict FBC normality.
全血细胞计数（FBC）的用途非常广泛，每个参数都可以作为辅助诊断和监测疾病进展的工具。然而，由于工作量增加和缺乏解释，该测试的有效性受到了阻碍。为了解决这个问题，评估了联合使用白细胞计数（WBC）和血红蛋白来预测 FBC 是否正常。
从 2191 名患者中收集了 FBC 数据，并根据 WBC 和血红蛋白是否在参考范围内将其分为两组。在每组异常的 FBC 样本中检查血涂片，并根据形态学进行分级。
在 WBC 和血红蛋白正常的情况下，FBC 正常的占 89.6%，其余的则存在细微异常；异常形态学的 1+分级占 93%。然而，当 WBC 和/或血红蛋白异常时，其余的 FBC 明显异常（P < 0.05），相应的血涂片也明显异常；异常形态学的 2+/3+分级占 96%。
我们得出结论，在 WBC 和血红蛋白正常的情况下，FBC 在几乎所有情况下都是正常的，测量这两个参数可以作为预测 FBC 是否正常的有效筛查手段。
