Abbas Abdul Baset, Aldomaini Abeer, Al-Qadri Amah Alrahman, Algorbani Zahra'a, Aljamali Sara, Alsiri Safa, Alghorbani Khadeeja, Abo Osba'a Saba
Medical Laboratories Department, Faculty of Medicine and Health Sciences, Ibb University, Ibb City, 70270, Yemen.
J Blood Med. 2024 Dec 19;15:513-522. doi: 10.2147/JBM.S488050. eCollection 2024.
Complete blood counts (CBC) are commonly used in diagnostic medicine to evaluate normal and abnormal hematological status. Furthermore, reference values (RVs) of CBC supplied by researchers are the most reliable means of the judgment-making stage and can aid interpretation and accurate diagnosis of diseases. Reference values vary between peoples because of differences in lifestyle, dietary habits, ethnicity and environment. Moreover, the Clinical and International Standards Institute (CISI) advises determining the RVs for each area. There are no RVs for CBC in Yemen. Therefore, this study aimed to determine the common RVs of CBC for healthy adults in Ibb City in the middle of Yemen.
A cross-sectional study was conducted from April 1, to November 30, 2023. Of the 623 adults who participated in this study, 433 (aged 18-80 years) were included in the final analysis after applying exclusion criteria. The mean, median, and 95 percentile RVs (2.5-97.5 percentiles) were calculated for gender, age, and residence by the GraphPad Prism 8.0.1.
The RVs of hemoglobin (Hb) 11.16-17.54g/dl, red blood cells (RBC) 3.890-6.340×10/l, hematocrit (HCT) 33.03-49.30%), mean corpuscular volume (MCV) 72.83-94.55fl), mean corpuscular hemoglobin (MCH) 23.95-33.55pg, mean corpuscular hemoglobin concentration (MCHC) 32.97-36.7354g/dl, platelet (PLT) count 140.0-418.6×10/l, total white blood cells (WBC) 2.810-8.797 ×10/l and WBC differential count (basophils 0.000-1.000%, neutrophils 30.10-69.17%, eosinophils 1.500-5.000%, lymphocytes 23.86-63.45% and monocytes1.873-5.600%). Significantly higher median values were observed in males compared to females for Hb (<0.0001), RBC (<0.0001), HCT (<0.0001), lymphocyte (=0.0197) and monocytes (=0.0009). Contrariwise, females demonstrated significantly higher neutrophils (=0.0009), eosinophils (=0.0020), basophils (<0.0001) and platelets (=0.0324) than males. This study showed differences in the RVs of CBC compared to those reported in other countries in the Middle East, Asia, Africa, and Europe.
In this study, the reference values of CBC are considered as a benchmark that may assist in accurately judging laboratory results and enhancing medical and clinical services for adults in Ibb City, Yemen.
全血细胞计数（CBC）常用于诊断医学中，以评估正常和异常的血液学状态。此外，研究人员提供的CBC参考值（RVs）是决策阶段最可靠的手段，有助于疾病的解释和准确诊断。由于生活方式、饮食习惯、种族和环境的差异，不同人群的参考值有所不同。此外，临床和国际标准协会（CISI）建议为每个地区确定参考值。也门尚无CBC的参考值。因此，本研究旨在确定也门中部伊卜市健康成年人CBC的常见参考值。
于2023年4月1日至11月30日进行了一项横断面研究。在参与本研究的623名成年人中，433名（年龄在18 - 80岁之间）在应用排除标准后被纳入最终分析。使用GraphPad Prism 8.0.1按性别、年龄和居住地计算平均、中位数和95百分位数参考值（2.5 - 97.5百分位数）。
血红蛋白（Hb）参考值为11.16 - 17.54g/dl，红细胞（RBC）为3.890 - 6.340×10⁶/μl，血细胞比容（HCT）为33.03 - 49.30%，平均红细胞体积（MCV）为72.83 - 94.55fl，平均红细胞血红蛋白（MCH）为23.95 - 33.55pg，平均红细胞血红蛋白浓度（MCHC）为32.97 - 36.73g/dl，血小板（PLT）计数为140.0 - 418.6×10⁹/μl，白细胞总数（WBC）为2.810 - 8.797×10⁹/μl，白细胞分类计数（嗜碱性粒细胞0.000 - 1.000%，中性粒细胞30.10 - 69.17%，嗜酸性粒细胞1.500 - 5.000%，淋巴细胞23.86 - 63.45%，单核细胞1.873 - 5.600%）。男性的Hb（<0.0001）、RBC（<0.0001）、HCT（<0.0001）、淋巴细胞（=0.0197）和单核细胞（=0.0009）的中位数显著高于女性。相反，女性的中性粒细胞（=0.0009）、嗜酸性粒细胞（=0.0020）、嗜碱性粒细胞（<0.0001）和血小板（=0.0324）显著高于男性。本研究显示，与中东、亚洲、非洲和欧洲其他国家报告的CBC参考值相比存在差异。
在本研究中，CBC的参考值被视为一个基准，可能有助于准确判断也门伊卜市成年人的实验室结果，并加强医疗和临床服务。
