Section of Cardiology, Internal Medicine, JiShuiTan Hospital, Beijing 100035, China.
Cardiovasc Ther. 2012 Aug;30(4):e183-8. doi: 10.1111/j.1755-5922.2011.00271.x. Epub 2011 Apr 1.
Ginsenosides are the bioactive constituents of ginseng, a key herb in traditional Chinese medicine. As a single component of ginseng, ginsenoside Re (G-Re) belongs to the panaxatriol group. Many reports demonstrated that G-Re possesses the multifaceted beneficial pharmacological effects on cardiovascular system. G-Re has negative effect on cardiac contractility and autorhythmicity. It causes alternations in cardiac electrophysiological properties, which may account for its antiarrhythmic effect. In addition, G-Re also exerts antiischemic effect and induces angiogenic regeneration. In this review, we first outline the chemistry and the pharmacological effects of G-Re on the cardiovascular system.
人参皂苷是人参的生物活性成分，是中药中的关键草药。作为人参的单一成分，人参皂苷 Re（G-Re）属于人参三醇组。许多报告表明，G-Re 对心血管系统具有多方面的有益的药理作用。G-Re 对心肌收缩力和自律性有负面影响。它导致心脏电生理特性的改变，这可能是其抗心律失常作用的原因。此外，G-Re 还具有抗缺血作用，并诱导血管生成再生。在这篇综述中，我们首先概述了 G-Re 的化学结构和对心血管系统的药理作用。
