Department of Zoology and Anthropology, Constantine the Philosopher University, Nábrežie mládeže 91, Nitra, Slovak Republic.
Acta Vet Scand. 2011 Aug 31;53(1):49. doi: 10.1186/1751-0147-53-49.
Exposure to cadmium (Cd) is considered a risk factor for various bone diseases in humans and experimental animals. This study investigated the acute effects of Cd on femoral bone structure of adult male rats after a single intraperitoneal administration.
Ten 4-month-old male Wistar rats were injected intraperitoneally with a single dose of 2 mg CdCl2/kg body weight and killed 36 h after the Cd had been injected. Ten 4-month-old males served as a control group. Differences in body weight, femoral weight, femoral length and histological structure of the femur were evaluated between the two groups of rats. The unpaired Student's t-test was used for establishment of statistical significance.
A single intraperitoneal administration of Cd had no significant effect on the body weight, femoral weight or femoral length. On the other hand, histological changes were significant. Rats exposed to Cd had significantly higher values of area, perimeter, maximum and minimum diameters of the primary osteons' vascular canals and Haversian canals. In contrast, a significant decrease in all variables of the secondary osteons was observed in these rats.
The results indicate that, as expected, a single intraperitoneal administration of 2 mg CdCl2/kg body weight had no impact on macroscopic structure of rat's femora; however, it affected the size of vascular canals of primary osteons, Haversian canals, and secondary osteons.
接触镉（Cd）被认为是人类和实验动物各种骨骼疾病的一个风险因素。本研究探讨了单次腹腔注射 Cd 对成年雄性大鼠股骨结构的急性影响。
10 只 4 月龄雄性 Wistar 大鼠单次腹腔内注射 2mgCdCl2/kg 体重，注射后 36 小时处死。10 只 4 月龄雄性大鼠作为对照组。比较两组大鼠体重、股骨重量、股骨长度和股骨组织学结构的差异。采用配对学生 t 检验建立统计学意义。
单次腹腔内注射 Cd 对体重、股骨重量或股骨长度没有显著影响。然而，组织学变化是显著的。暴露于 Cd 的大鼠初级骨单位血管腔和哈弗氏管的面积、周长、最大和最小直径显著升高。相反，这些大鼠的次级骨单位的所有变量都显著下降。
结果表明，预期单次腹腔内注射 2mgCdCl2/kg 体重对大鼠股骨的宏观结构没有影响；然而，它影响了初级骨单位、哈弗氏管和次级骨单位的血管腔大小。
