Omelka Radoslav, Blahova Jana, Kovacova Veronika, Babikova Martina, Mondockova Vladimira, Kalafova Anna, Capcarova Marcela, Martiniakova Monika
Department of Botany and Genetics, Faculty of Natural Sciences, Constantine the Philosopher University in Nitra, 949 74 Nitra, Slovakia.
Department of Zoology and Anthropology, Faculty of Natural Sciences, Constantine the Philosopher University in Nitra, 949 74 Nitra, Slovakia.
Animals (Basel). 2020 Dec 19;10(12):2435. doi: 10.3390/ani10122435.
Cornelian cherry ( L.) is a medicinal plant with a range of biological features. It is often used as a nutritional supplement in the treatment of diabetes mellitus. Our study was aimed to first investigate the effects of Cornelian cherry pulp on bone quality parameters in Zucker diabetic fatty (ZDF) rats. Moreover, lipid-lowering properties of this fruit were also evaluated. Adult rats (n = 28) were assigned into four groups of seven individuals each: L group (non-diabetic lean rats), C group (diabetic obese rats), and E1 and E2 groups (diabetic obese rats receiving 500 and 1000 mg/kg body weight of Cornelian cherry pulp, respectively, for 10 weeks). Significantly lower levels of triglyceride, total cholesterol and alkaline phosphatase activity were determined in the E2 group versus the C group. A higher dose of also had a beneficial impact on femoral weight, cortical bone thickness, relative volume of trabecular bone and trabecular thickness. We observed elevated density of Haversian systems and accelerated periosteal bone apposition in both treated groups (E1 and E2). Our results clearly demonstrate that Cornelian cherry pulp has a favorable effect on lipid disorder and impaired bone quality consistent with type 2 diabetes mellitus in a suitable animal model.
欧洲山茱萸是一种具有多种生物学特性的药用植物。它常被用作治疗糖尿病的营养补充剂。我们的研究旨在首先探究欧洲山茱萸果肉对Zucker糖尿病肥胖（ZDF）大鼠骨质量参数的影响。此外，还评估了这种水果的降脂特性。成年大鼠（n = 28）被分为四组，每组七只：L组（非糖尿病瘦大鼠）、C组（糖尿病肥胖大鼠）以及E1组和E2组（分别接受500和1000 mg/kg体重欧洲山茱萸果肉处理10周的糖尿病肥胖大鼠）。与C组相比，E2组的甘油三酯、总胆固醇水平及碱性磷酸酶活性显著降低。较高剂量的欧洲山茱萸果肉对股骨重量、皮质骨厚度、小梁骨相对体积和小梁厚度也有有益影响。我们观察到两个处理组（E1和E2）的哈弗斯系统密度升高且骨膜骨沉积加速。我们的结果清楚地表明，在合适的动物模型中，欧洲山茱萸果肉对与2型糖尿病相关的脂质紊乱和骨质量受损具有有利影响。
