Department of Medical and Surgical Sciences, Geriatrics Division, University of Padova, via Giustiniani 2, Padua, Italy.
Exp Gerontol. 2011 Nov;46(11):929-33. doi: 10.1016/j.exger.2011.08.008. Epub 2011 Aug 22.
Inflammatory states, hypovitaminosis D and secondary hyperparathyroidism may have a role in the age-related loss of muscle mass, and physical performance in healthy old people. The aim of this study is to investigate changes in muscle mass, strength and physical performance in healthy, active elderly females over a 3-year follow-up, correlating them with any inflammatory states and PTH and 25-hydroxyvitamin D (25-OHD) levels.
One hundred healthy females over 65 years of age routinely attending a twice-weekly mild fitness program were eligible for the study. Clinical history, serum parameters, body composition by DEXA, handgrip strength, knee extensor isometric/isotonic strength and functional performance measured using the Short Physical Performance Battery (SPPB) were evaluated at the baseline and after 3 years.
After 3 years, the women had a significant decrease in weight (∆:-0.8±3.1 kg; p<0.05) and height (∆:-0.4±0,6 cm; p<0.001), while their BMI and body composition parameters did not change. Only IL-6 (∆: 0.6±2.0; p<0.01) and PTH (∆: 30.7±29.2 ng/L; p<0.001) increased significantly, while there were no changes in 25-OHD levels. There was a significant decrease in all the SPPB results and in muscle strength. ∆ PTH only correlated with the variation in 4-meter walking speed (r: 0.41; p<0.01).
With advancing age, physical performance declines even in healthy, active females despite a spare of muscle mass. The increase in PTH seems to have a role in this decline, that could be clarified by further investigations.
在健康的老年人中，炎症状态、维生素 D 缺乏症和继发性甲状旁腺功能亢进可能与肌肉质量随年龄的下降以及身体机能下降有关。本研究旨在探讨健康、活跃的老年女性在 3 年随访期间肌肉质量、力量和身体机能的变化，并将其与任何炎症状态、甲状旁腺激素（PTH）和 25-羟维生素 D（25-OHD）水平相关联。
100 名年龄在 65 岁以上、定期参加每周两次的轻度健身计划的健康女性符合研究条件。在基线和 3 年后评估临床病史、血清参数、DEXA 测定的身体成分、握力、膝关节等长/等速力量以及使用短体物理性能电池（SPPB）测量的功能性表现。
3 年后，女性体重（∆：-0.8±3.1 kg；p<0.05）和身高（∆：-0.4±0.6 cm；p<0.001）显著下降，而 BMI 和身体成分参数没有变化。只有白细胞介素 6（∆：0.6±2.0；p<0.01）和 PTH（∆：30.7±29.2 ng/L；p<0.001）显著增加，而 25-OHD 水平没有变化。所有 SPPB 结果和肌肉力量均显著下降。∆PTH 仅与 4 米步行速度的变化相关（r：0.41；p<0.01）。
即使在健康、活跃的女性中，随着年龄的增长，身体机能也会下降，尽管肌肉质量保持不变。PTH 的增加似乎与这种下降有关，这可以通过进一步的研究来阐明。
