Department of Medical and Surgical Specialties and Dentistry, University of Campania "Luigi Vanvitelli", Naples, Italy -
Department of Surgical, Oncologic and Stomatologic Disciplines, University of Palermo, Palermo, Italy.
Eur J Phys Rehabil Med. 2018 Oct;54(5):676-682. doi: 10.23736/S1973-9087.17.04533-6. Epub 2017 Jul 10.
The presence of the vitamin D receptor (VDR) has been recently demonstrated in human muscle supporting the theory of a role of vitamin D in the proliferation and differentiation of muscle cells. So far only few studies investigated the association between vitamin D and muscle performance in postmenopausal women.
To define the functional impact of vitamin D deficiency.
Multicenter retrospective study.
Five Italian outpatient services of Physical and Rehabilitation Medicine (PRM).
Postmenopausal women.
We divided the population in two groups based on the threshold of 30 ng/mL as cut-off to define sufficient and insufficient serum levels of 25-hydroxyvitamin D3 [25(OH)D3]. Outcome measures were: appendicular lean mass (ALM); ALM-to-BMI ratio (ALMBMI); total fat mass (FM); visceral adipose tissue (VAT); Hand Grip Strength (HGS); Knee Isometric Extension Strength (KES); Short Physical Performance Battery (SPPB); 4-meter gait speed (4MGS).
We analyzed the data records of 401 postmenopausal women (mean age 66.93±8.47 years): 203 with hypovitaminosis D (mean age 66.81±8.11 years) and 198 with normal levels of 25(OH)D3 (mean age 67.04±8.84 years). The analysis showed a significant difference between the two groups in terms of: ALMBMI (0.002), FM (P<0.001), VAT mass (0.010), VAT volume (P=0.006), HGS (P<0.001), KES (P<0.001), SPPB score (P<0.001), percentage of people with a 4MGS≤0.8 m/s (P<0.001). Furthermore, there were significant correlations (P<0.001) between serum levels of 25(OH)D3 and HGS (r=0.323), KES (r=0.510), and SPPB sit to stand (r=-0.362) and walking sub-scores (r=-0.312).
This multicenter study demonstrated that postmenopausal women with vitamin D deficiency had a significant reduction of appendicular muscle strength and physical performance.
This study reported the frequency of hypovitaminosis D in postmenopausal women and its influence on the reduction of muscle mass, strength, and physical performance in a typical population referring to the physiatrist for musculoskeletal disorders.
最近在人类肌肉中发现了维生素 D 受体 (VDR)，这支持了维生素 D 在肌肉细胞增殖和分化中的作用理论。到目前为止，只有少数研究调查了维生素 D 与绝经后妇女肌肉功能之间的关系。
定义维生素 D 缺乏的功能影响。
多中心回顾性研究。
意大利五个物理和康复医学（PRM）门诊服务处。
绝经后妇女。
我们根据 30ng/mL 的阈值将人群分为两组，以定义 25-羟维生素 D3 [25(OH)D3] 的充足和不足血清水平。主要观察指标为：四肢瘦体重（ALM）；四肢瘦体重与 BMI 的比值（ALMBMI）；总脂肪量（FM）；内脏脂肪组织（VAT）；手握力（HGS）；膝关节等长伸肌强度（KES）；短程体能测试（SPPB）；4 米步速（4MGS）。
我们分析了 401 名绝经后妇女（平均年龄 66.93±8.47 岁）的数据记录：203 名维生素 D 缺乏症患者（平均年龄 66.81±8.11 岁）和 198 名 25(OH)D3 水平正常者（平均年龄 67.04±8.84 岁）。分析显示两组之间在以下方面存在显著差异：ALMBMI（0.002）、FM（P<0.001）、VAT 质量（P<0.001）、VAT 体积（P=0.010）、HGS（P<0.001）、KES（P<0.001）、SPPB 评分（P<0.001）、4MGS≤0.8m/s 的人数百分比（P<0.001）。此外，血清 25(OH)D3 水平与 HGS（r=0.323）、KES（r=0.510）和 SPPB 从坐到站（r=-0.362）和步行子评分（r=-0.312）之间存在显著相关性（P<0.001）。
这项多中心研究表明，维生素 D 缺乏的绝经后妇女四肢肌肉力量和身体表现明显下降。
本研究报告了绝经后妇女中维生素 D 缺乏的频率及其对肌肉质量、力量和身体表现降低的影响，这是在肌肉骨骼疾病向理疗师就诊的典型人群中观察到的。
