口服β-羟基-β-甲基丁酸酯（HMB）对65岁以上健康老年女性身体机能的影响：一项开放标签随机对照试验。
Effect of Oral Beta-Hydroxy-Beta-Methylbutyrate (HMB) Supplementation on Physical Performance in Healthy Old Women Over 65 Years: An Open Label Randomized Controlled Trial.
作者信息
Berton Linda, Bano Giulia, Carraro Sara, Veronese Nicola, Pizzato Simona, Bolzetta Francesco, De Rui Marina, Valmorbida Elena, De Ronch Irene, Perissinotto Egle, Coin Alessandra, Manzato Enzo, Sergi Giuseppe
机构信息
University of Padova, Department of Medicine-DIMED, Geriatrics Division, Via Giustiniani 2, 35128 Padova, Italy.
University of Padova, Department of Cardiac, Thoracic and Vascular Sciences, Biostatistics, Epidemiology and Public Health Unit, Via Loredan 18, 35128 Padova, Italy.
出版信息
PLoS One. 2015 Nov 3;10(11):e0141757. doi: 10.1371/journal.pone.0141757. eCollection 2015.
UNLABELLED
Although older people are particularly liable to sarcopenia, limited research is available on beta-hydroxy-beta-methylbutyrate (HMB) supplementation in this population, particularly in healthy subjects. In this parallel-group, randomized, controlled, open-label trial, we aimed to evaluate whether an oral supplement containing 1.5 g of calcium HMB for 8 weeks could improve physical performance and muscle strength parameters in a group of community-dwelling healthy older women. Eighty healthy women attending a twice-weekly mild fitness program were divided into two equal groups of 40, and 32 of the treated women and 33 control completed the study. We considered a change in the Short Physical Performance Battery (SPPB) score as the primary outcome and changes in the peak torque (PT) isometric and isokinetic strength of the lower limbs, 6-minute walking test (6MWT), handgrip strength and endurance as secondary outcomes. Body composition was assessed with dual-energy X-ray absorptiometry (DXA) and peripheral quantitative computerized tomography (pQCT). The mean difference between the two groups on pre-post change were finally calculated (delta) for each outcome. After 8 weeks, there were no significant differences between the groups’ SPPB, handgrip strength or DXA parameters. The group treated with HMB scored significantly better than the control group for PT isokinetic flexion (delta = 1.56±1.56 Nm; p = 0.03) and extension (delta = 3.32±2.61 Nm; p = 0.03), PT isometric strength (delta = 9.74±3.90 Nm; p = 0.02), 6MWT (delta = 7.67±8.29 m; p = 0.04), handgrip endurance (delta = 21.41±16.28 s; p = 0.02), and muscle density assessed with pQCT. No serious adverse effects were reported in either group. In conclusion, a nutritional supplement containing 1.5 g of calcium HMB for 8 weeks in healthy elderly women had no significant effects on SPPB, but did significantly improve several muscle strength and physical performance parameters.
TRIAL REGISTRATION
ClinicalTrials.gov NCT02118181.
未标注
尽管老年人特别容易患肌肉减少症，但关于β-羟基-β-甲基丁酸酯（HMB）补充剂在该人群中的研究有限，尤其是在健康受试者中。在这项平行组、随机、对照、开放标签试验中，我们旨在评估连续8周口服含1.5克HMB钙的补充剂是否能改善一组社区居住的健康老年女性的身体机能和肌肉力量参数。80名参加每周两次轻度健身计划的健康女性被平均分为两组，每组40人，治疗组的32名女性和33名对照组女性完成了研究。我们将简短身体机能测试（SPPB）评分的变化作为主要结果，将下肢等长和等速力量的峰值扭矩（PT）变化、6分钟步行试验（6MWT）、握力和耐力作为次要结果。采用双能X线吸收法（DXA）和外周定量计算机断层扫描（pQCT）评估身体成分。最终计算两组在各结果前后变化的平均差异（差值）。8周后，两组在SPPB、握力或DXA参数方面无显著差异。HMB治疗组在PT等速屈曲（差值 = 1.56±1.56 Nm；p = 0.03）和伸展（差值 = 3.32±2.61 Nm；p = 0.03）、PT等长力量（差值 = 9.74±3.90 Nm；p = 0.02）、6MWT（差值 = 7.67±8.29 m；p = 0.04）、握力耐力（差值 = 21.41±16.28 s；p = 0.02）以及用pQCT评估的肌肉密度方面的得分显著高于对照组。两组均未报告严重不良反应。总之，健康老年女性连续8周口服含1.5克HMB钙的营养补充剂对SPPB无显著影响，但确实显著改善了多项肌肉力量和身体机能参数。
试验注册
ClinicalTrials.gov NCT02118181。
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