Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Mol Cell Neurosci. 2012 Mar;49(3):387-93. doi: 10.1016/j.mcn.2011.08.006. Epub 2011 Aug 22.
Extracellular signaling between cells is often transduced via receptors that reside at the cell membrane. In neurons this receptor-mediated signaling can promote a variety of cellular events such as differentiation, axon outgrowth and guidance, and synaptic development and function. Endocytic membrane trafficking of receptors ensures that the strength and duration of an extracellular signal is properly regulated. The covalent modification of membrane proteins by ubiquitin is a key biological mechanism controlling receptor internalization and endocytic sorting to recycling and degradative pathways in many cell types. In this review we highlight recent findings regarding the ubiquitin-dependent trafficking and turnover of receptors in neurons and the implications for neuronal development and function.
细胞间的细胞外信号通常通过位于细胞膜上的受体进行转导。在神经元中，这种受体介导的信号转导可以促进多种细胞事件，如分化、轴突生长和导向以及突触的发育和功能。受体的内吞膜运输确保了细胞外信号的强度和持续时间得到适当调节。在许多细胞类型中，通过泛素对膜蛋白进行共价修饰是控制受体内化和内吞分选到再循环和降解途径的关键生物学机制。在这篇综述中，我们强调了最近关于神经元中受体的泛素依赖性运输和周转的发现，以及它们对神经元发育和功能的影响。
