Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA, USA.
Am Heart J. 2011 Sep;162(3):538-41. doi: 10.1016/j.ahj.2011.06.013. Epub 2011 Aug 11.
Atrial fibrillation (AF) is common and is an important cause of cardiovascular morbidity and mortality. Vitamin D is an emerging risk factor in cardiovascular disease, and vitamin D status is modifiable. Thus, we sought to investigate whether vitamin D status predisposed to the development of AF in a community-based sample.
We evaluated the relation between vitamin D status and development of AF in 2,930 participants of the Framingham Heart Study, Massachusetts, USA, without prevalent AF. The mean age was 65 ± 11 years, and 56% were women. Vitamin D status was assessed by measuring 25-hydroxyvitamin D (25[OH]D) concentrations. Multivariable Cox regression models were adjusted for AF risk factors and season.
During a mean follow-up of 9.9 years, 425 participants (15%) developed AF. In Cox proportional hazards models, 25(OH)D was not associated with development of AF, with a multivariable-adjusted hazard ratio of 0.99 per SD increment in 25(OH)D levels (95% CI 0.88-1.10, P = .81). Also, no relation was found in models including 25(OH)D as a dichotomous variable (above and below the cohort-specific 20th percentile; P = .59).
In our community-based sample, vitamin D status was not related to incident AF. Our data suggest that vitamin D deficiency does not promote the development of AF in the ambulatory setting.
心房颤动（AF）很常见，是心血管发病率和死亡率的重要原因。维生素 D 是心血管疾病的一个新兴危险因素，且维生素 D 状态是可改变的。因此，我们试图在一个基于社区的样本中研究维生素 D 状态是否会导致 AF 的发生。
我们评估了美国马萨诸塞州弗雷明汉心脏研究 2930 名无明显 AF 参与者的维生素 D 状态与 AF 发生之间的关系。平均年龄为 65±11 岁，56%为女性。通过测量 25-羟维生素 D（25[OH]D）浓度来评估维生素 D 状态。多变量 Cox 回归模型调整了 AF 危险因素和季节。
在平均 9.9 年的随访期间，425 名参与者（15%）发生了 AF。在 Cox 比例风险模型中，25（OH）D 与 AF 发生无关，25（OH）D 水平每增加一个标准差，多变量调整后的风险比为 0.99（95%CI 0.88-1.10，P=.81）。此外，在包括 25（OH）D 作为二分类变量（高于和低于队列特定的第 20 百分位数）的模型中也未发现相关性（P=.59）。
在我们的基于社区的样本中，维生素 D 状态与新发 AF 无关。我们的数据表明，在门诊环境中，维生素 D 缺乏不会促进 AF 的发生。
