Division of Ophthalmology and Visual Sciences, University of Nottingham, Eye Ear Nose Throat Centre, University Hospital, Nottingham, United Kingdom.
Cont Lens Anterior Eye. 2012 Feb;35(1):39-45. doi: 10.1016/j.clae.2011.07.004. Epub 2011 Aug 31.
To study the thickness profile of the normal cornea in order to establish any correlation between central and peripheral points.
Sixty-seven eyes of 40 patients were subjected to central corneal thickness measurement (CCT) with an ultrasound pachymeter (UP) and corneal thickness mapping with the Oculus Pentacam. The corneal apex thickness (CAT), pupil centre thickness (recorded as CCT and corresponded to CCT of UP) and thickness at the thinnest location (CTL) were obtained and compared with each other. Corneal thickness data at 3 mm and 7 mm temporally, nasally, superiorly and inferiorly from the corneal apex were obtained. The mean corneal thickness values along the 2, 4, 6, 8 and 10 mm diameter concentric circles, with the CTL as the centre, were also obtained. The above data at different points were statistically correlated.
There was no significant difference between CCT readings measured by UP and Pentacam (P=0.721). There was high positive correlation between the CAT values and the thickness at 3 mm (R≥0.845, P<0.001) and at 7 mm points (R≥0.654, P<0.001). A gradual increase in thickness was noted from the centre to the periphery with a high positive correlation between the CTL values and the mean thickness at the circles of 2, 4, 6, 8 and 10 mm (R≥0.635, P<0.001).
The results suggest that central corneal thickness can serve as a good guide for predicting peripheral thickness. For surgical procedures specifically undertaken at mid-peripheral and peripheral zones, the actual measurements at the site of surgery may confer some advantage.
研究正常角膜的厚度分布，以确定中央点和周边点之间的相关性。
对 40 例 67 只眼分别行超声角膜测厚仪（UP）中央角膜厚度（CCT）测量和 Oculus Pentacam 角膜厚度图检测。获取角膜顶点厚度（CAT）、瞳孔中心厚度（记录为 CCT，与 UP 的 CCT 相对应）和最薄位置厚度（CTL），并对三者进行比较。还分别获取角膜顶点 3mm 和 7mm 处的颞侧、鼻侧、上侧和下侧的角膜厚度数据。获取以 CTL 为中心，沿 2、4、6、8 和 10mm 直径同心环的角膜平均厚度值。对不同部位的上述数据进行统计学相关性分析。
UP 和 Pentacam 测量的 CCT 读数无显著差异（P=0.721）。CAT 值与 3mm（R≥0.845，P<0.001）和 7mm 处（R≥0.654，P<0.001）的厚度高度正相关。从中心到周边，厚度逐渐增加，CTL 值与 2、4、6、8 和 10mm 环的平均厚度之间存在高度正相关（R≥0.635，P<0.001）。
结果表明，中央角膜厚度可以很好地预测周边厚度。对于专门在中周和周边区域进行的手术程序，手术部位的实际测量可能会带来一些优势。
