Murphy J R, Clyde D F, Herrington D A, Baqar S, Davis J R, Palmer K, Cortese J
Department of Medicine, School of Medicine, University of Maryland, Baltimore 21201.
Antimicrob Agents Chemother. 1990 Apr;34(4):676-9. doi: 10.1128/AAC.34.4.676.
Volunteers infected with a chloroquine-susceptible line of Plasmodium falciparum were administered standard oral chloroquine therapy at the first detection of parasites in the blood. Parasitemias progressed in the face of therapy for up to 5 days and to levels up to 100-fold greater than those at the initiation of treatment. Thereafter, infections cleared without a requirement for additional chemotherapy. This course of infection and response to treatment has not been previously reported and may have been detected because volunteers were exposed to an unusually large number of sporozoites. The observations are consistent with the hypothesis that prolonged parasitemia resulted from the continued release of merozoites from liver.
感染对氯喹敏感的恶性疟原虫品系的志愿者在血液中首次检测到寄生虫时接受标准口服氯喹治疗。尽管进行了治疗，但寄生虫血症仍持续进展长达5天，且达到比治疗开始时高100倍的水平。此后，感染自行清除，无需额外化疗。此前尚未报道过这种感染过程和对治疗的反应，可能是因为志愿者接触了异常大量的子孢子才得以检测到。这些观察结果与以下假设一致，即长期寄生虫血症是由于裂殖子从肝脏持续释放所致。
