Davis J R, Murphy J R, Clyde D F, Baqar S, Cochrane A H, Zavala F, Nussenzweig R S
Department of Medicine, University of Maryland School of Medicine, Baltimore.
Am J Trop Med Hyg. 1989 Feb;40(2):128-30. doi: 10.4269/ajtmh.1989.40.128.
Plasmodium falciparum infected Anopheles stephensi, taken from a group of mosquitoes which had been used to challenge recipients of (NANP)3-TT vaccine, were tested for P. falciparum sporozoite content by an immunoradiometric assay. Seventy-six percent were infected with mean and median sporozoite equivalents per mosquito of 220,994 and 217,398, respectively (SD = 54,911). This sporozoite density is greater than that usually found in the field. These data suggest that this challenge for evaluating P. falciparum sporozoite vaccines is a demanding test of immunity.
从一组曾用于攻击（NANP）3-TT疫苗接种者的斯氏按蚊中选取感染恶性疟原虫的蚊子，通过免疫放射分析检测其恶性疟原虫子孢子含量。76%的蚊子受到感染，每只蚊子子孢子当量的均值和中位数分别为220,994和217,398（标准差=54,911）。这种子孢子密度高于在野外通常发现的密度。这些数据表明，这种评估恶性疟原虫子孢子疫苗的攻击是对免疫力的一项严格测试。
