Tamí-Maury Irene M, Willig James H, Jolly Pauline E, Vermund Sten, Aban Inmaculada, Hill Jeffery D, Wilson Craig M, Kempf Mirjam-Collette
Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA.
South Med J. 2011 Aug;104(8):561-6. doi: 10.1097/SMJ.0b013e318224a15f.
Our aim was to quantify prevalence, incidence, and recurrence of oral lesions (OL) among a population in the Southeast.
A retrospective study based on chart review was conducted among patients (n = 744) who were ≥19 years of age and initiated highly active antiretroviral therapy (HAART) between January 2000 and June 2006 at the University of Alabama at Birmingham (UAB) 1917 Clinic. Patients' laboratory data and oral conditions were recorded for 2 years after enrollment into the study.
During 2 years of follow-up, the period prevalence of individuals experienced at least one OL was 35.6% (266/744). Among all of the 374 episodes of OL, 183 were new cases, while 57 were recurrences. The OL person-visit incidence rate was 0.02 per 100 person-visits. Oropharyngeal candidiasis (OPC) was the most frequent manifestation in terms of period prevalence (74.9%) with a person-visit incident rate of 0.01 per 100 person-visits.
Patients undergoing HAART continue to be affected by HIV-related oral conditions, especially OPC. These results clearly indicate that OL during HIV infection are still highly prevalent in spite of the improvements in medical care and the availability of HAART.
我们的目标是量化东南部人群中口腔病变（OL）的患病率、发病率和复发率。
对2000年1月至2006年6月期间在阿拉巴马大学伯明翰分校（UAB）1917诊所开始接受高效抗逆转录病毒治疗（HAART）且年龄≥19岁的患者（n = 744）进行了一项基于病历回顾的回顾性研究。在患者入组研究后的2年中记录其实验室数据和口腔状况。
在2年的随访期间，经历过至少一次OL的个体的期间患病率为35.6%（266/744）。在所有374次OL发作中，183例为新发病例，57例为复发。OL的人次发病率为每100人次0.02。就期间患病率而言，口腔念珠菌病（OPC）是最常见的表现（74.9%），人次发病率为每100人次0.01。
接受HAART治疗的患者仍受与HIV相关的口腔疾病影响，尤其是OPC。这些结果清楚地表明，尽管医疗护理有所改善且有HAART可用，但HIV感染期间的OL仍然非常普遍。
