泰国人类免疫缺陷病毒感染孕妇牙周炎和口腔表现与 CD4 计数的相关性。
Associations of periodontitis and oral manifestations with CD4 counts in human immunodeficiency virus-pregnant women in Thailand.
机构信息
Faculty of Dentistry, Thammasat University, Pathumthani, Thailand.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Sep;116(3):306-12. doi: 10.1016/j.oooo.2013.04.016. Epub 2013 Jun 19.
OBJECTIVES
To investigate the associations of CD4 count with chronic periodontitis and human immunodeficiency virus (HIV)-related oral lesions in pregnant HIV-infected Thai women.
STUDY DESIGN
Two hundred ninety-two HIV-infected pregnant women were interviewed for health information and examined for their periodontal condition and HIV-related oral lesions during weeks 16-34 of gestation. Logistic regression, t tests and Chi-squared tests were used to examine the associations of CD4 count with oral lesions and periodontal conditions.
RESULTS
One hundred thirty-three women (45.6%) had at least 1 tooth with a periodontal pocket over 4 mm. Thirty-eight (17.76%) subjects had oral candidiasis and 53 subjects (24.77%) had oral hairy leukoplakia (OHL). Low CD4 count was significantly associated with periodontitis at odds ratio (OR) = 2.06 with 95% confidence interval (CI) = [1.00-4.27], P = .05. A significant association was found for low CD4 count with OHL with OR = 3.57, 95% CI = [1.34-9.46], P = .01.
CONCLUSIONS
Chronic periodontitis and OHL were associated with CD4 count lower than 200 cells/mm(3) in HIV-infected women.
目的
调查 CD4 计数与慢性牙周炎和人类免疫缺陷病毒（HIV）相关口腔病变在泰国 HIV 感染孕妇中的相关性。
研究设计
292 名 HIV 感染孕妇在妊娠 16-34 周期间接受健康信息访谈，并检查其牙周状况和 HIV 相关口腔病变。使用逻辑回归、t 检验和卡方检验来检验 CD4 计数与口腔病变和牙周状况的相关性。
结果
133 名女性（45.6%）至少有 1 颗牙齿的牙周袋深度超过 4 毫米。38 名（17.76%）受试者患有口腔念珠菌病，53 名（24.77%）受试者患有口腔毛状白斑（OHL）。低 CD4 计数与牙周炎显著相关，比值比（OR）=2.06，95%置信区间（CI）=[1.00-4.27]，P=0.05。低 CD4 计数与 OHL 也存在显著相关性，OR=3.57，95%CI=[1.34-9.46]，P=0.01。
结论
慢性牙周炎和 OHL 与 HIV 感染女性的 CD4 计数低于 200 个细胞/mm(3)有关。
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