生物反应器在肌肉骨骼应用组织工程中的作用。
The role of bioreactors in tissue engineering for musculoskeletal applications.
作者信息
Oragui Emeka, Nannaparaju Madhusudhan, Khan Wasim S
机构信息
Department of Trauma and Orthopaedics, Barking, Havering and Redbridge NHS Trust, Romford, UK.
出版信息
Open Orthop J. 2011;5 Suppl 2:267-70. doi: 10.2174/1874325001105010267. Epub 2011 Jul 28.
Abstract
Tissue engineering involves using the principles of biology, chemistry and engineering to design a 'neotissue' that augments a malfunctioning in vivo tissue. The main requirements for functional engineered tissue include reparative cellular components that proliferate on a biocompatible scaffold grown within a bioreactor that provides specific biochemical and physical signals to regulate cell differentiation and tissue assembly. We discuss the role of bioreactors in tissue engineering and evaluate the principles of bioreactor design. We evaluate the methods of cell stimulation and review the bioreactors in common use today.
摘要
组织工程涉及运用生物学、化学和工程学原理来设计一种“新组织”，以增强体内功能失常的组织。功能性工程组织的主要要求包括可修复的细胞成分，这些细胞成分能在生物反应器内生长的生物相容性支架上增殖，该生物反应器可提供特定的生化和物理信号来调节细胞分化和组织组装。我们讨论了生物反应器在组织工程中的作用，并评估了生物反应器的设计原理。我们评估了细胞刺激方法，并综述了当今常用的生物反应器。
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