Cordelle Maira Z, Snelling Sarah J B, Mouthuy Pierre-Alexis
Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7LD, UK.
Cyborg Bionic Syst. 2025 May 15;6:0279. doi: 10.34133/cbsystems.0279. eCollection 2025.
With its remarkable adaptability, energy efficiency, and mechanical compliance, skeletal muscle is a powerful source of inspiration for innovations in engineering and robotics. Originally driven by the clinical need to address large irreparable muscle defects, skeletal muscle tissue engineering (SMTE) has evolved into a versatile strategy reaching beyond medical applications into the field of biorobotics. This review highlights recent advancements in SMTE, including innovations in scaffold design, cell sourcing, usage of external physicochemical cues, and bioreactor technologies. Furthermore, this article explores the emerging synergies between SMTE and robotics, focusing on the use of robotic systems to enhance bioreactor performance and the development of biohybrid devices integrating engineered muscle tissue. These interdisciplinary approaches aim to improve functional recovery outcomes while inspiring novel biohybrid technologies at the intersection of engineering and regenerative medicine.
凭借其卓越的适应性、能源效率和机械顺应性，骨骼肌是工程和机器人技术创新的强大灵感来源。骨骼肌组织工程（SMTE）最初是由解决大面积无法修复的肌肉缺损的临床需求驱动的，如今已发展成为一种通用策略，从医疗应用扩展到生物机器人领域。本综述重点介绍了SMTE的最新进展，包括支架设计、细胞来源、外部物理化学线索的应用以及生物反应器技术等方面的创新。此外，本文还探讨了SMTE与机器人技术之间新出现的协同作用，重点关注利用机器人系统提高生物反应器性能以及开发集成工程肌肉组织的生物混合装置。这些跨学科方法旨在改善功能恢复结果，同时激发工程学与再生医学交叉领域的新型生物混合技术。
