Punwar Shahid, Khan Wasim S
Department of Trauma and Orthopaedics, Frenchay Hospital, North Bristol NHS Trust, Bristol, BS16 1LE, UK.
Open Orthop J. 2011;5 Suppl 2:296-301. doi: 10.2174/1874325001105010296. Epub 2011 Jul 28.
Cartilage is frequently injured but shows little capacity for repair. Current treatment options include the use of procedures that stimulate repair through the stimulation of subchondral bone marrow and result in the formation of fibrocartilage. There is considerable interest in the use of cell-based treatment strategies and there are limited studies describing the use of mesenchymal stem cells for cartilage repair with promising early results. This paper reviews the current treatment strategies for articular cartilage, describes use of mesenchymal stem cells for articular cartilage repair along with the results of clinical studies, and describes the future direction that these strategies are likely to take.
软骨经常受损，但修复能力很差。目前的治疗选择包括通过刺激软骨下骨髓来促进修复并形成纤维软骨的方法。基于细胞的治疗策略备受关注，目前仅有有限的研究描述了使用间充质干细胞修复软骨并取得了有前景的早期结果。本文综述了目前关节软骨的治疗策略，描述了间充质干细胞在关节软骨修复中的应用以及临床研究结果，并阐述了这些策略可能的未来发展方向。
