Chularojanamontri Leena, Tuchinda Papapit, Kulthanan Kanokvalai, Manuskiatti Woraphong
Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
J Dermatol Case Rep. 2010 Dec 31;4(4):60-2. doi: 10.3315/jdcr.2010.1059.
Diphencyprone is a universal contact immunotherapy. The mechanism of action is based on an induction of the delayed-type hypersensitivity. Diphencyprone has been used in various forms for treatments of recalcitrant and facial warts, and alopecia areata. However, this treatment modality has not been generally used in immunocompromised patients.
The present report demonstrated the efficacy of diphencyprone immunotherapy on the treatment of generalized molluscum contagiosum in a human immunodeficiency virus (HIV)-infected patient. Minimal and transient side effects including pruritus, postinflammatory hyperpigmentation and irritation were noted.
Diphencyprone contact immunotherapy appears to be a possible alternative treatment of widespread molluscum contagiosum in immunocompromised patients.
二苯环丙烯酮是一种通用的接触免疫疗法。其作用机制基于迟发型超敏反应的诱导。二苯环丙烯酮已以多种形式用于治疗顽固性和面部疣以及斑秃。然而，这种治疗方式尚未普遍用于免疫功能低下的患者。
本报告证明了二苯环丙烯酮免疫疗法对一名感染人类免疫缺陷病毒（HIV）的患者的泛发性传染性软疣的治疗效果。观察到了包括瘙痒、炎症后色素沉着和刺激在内的轻微且短暂的副作用。
二苯环丙烯酮接触免疫疗法似乎是免疫功能低下患者广泛存在的传染性软疣的一种可能的替代治疗方法。
