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琥珀酸密螺旋体模式菌株(6091)的全基因组序列

Complete genome sequence of Treponema succinifaciens type strain (6091).

作者信息

Han Cliff, Gronow Sabine, Teshima Hazuki, Lapidus Alla, Nolan Matt, Lucas Susan, Hammon Nancy, Deshpande Shweta, Cheng Jan-Fang, Zeytun Ahmed, Tapia Roxanne, Goodwin Lynne, Pitluck Sam, Liolios Konstantinos, Pagani Ioanna, Ivanova Natalia, Mavromatis Konstantinos, Mikhailova Natalia, Huntemann Marcel, Pati Amrita, Chen Amy, Palaniappan Krishna, Land Miriam, Hauser Loren, Brambilla Evelyne-Marie, Rohde Manfred, Göker Markus, Woyke Tanja, Bristow James, Eisen Jonathan A, Markowitz Victor, Hugenholtz Philip, Kyrpides Nikos C, Klenk Hans-Peter, Detter John C

出版信息

Stand Genomic Sci. 2011 Jul 1;4(3):361-70. doi: 10.4056/sigs.1984594. Epub 2011 Jun 30.

Abstract

Treponema succinifaciens Cwyk and Canale-Parola 1981 is of interest because this strictly anaerobic, apathogenic member of the genus Treponema oxidizes carbohydrates and couples the Embden-Meyerhof pathway via activity of a pyruvate-formate lyase to the production of acetyl-coenzyme A and formate. This feature separates this species from most other anaerobic spirochetes. The genome of T. succinifaciens 6091(T) is only the second completed and published type strain genome from the genus Treponema in the family Spirochaetaceae. The 2,897,425 bp long genome with one plasmid harbors 2,723 protein-coding and 63 RNA genes and is a part of the Genomic Encyclopedia of Bacteria and Archaea project.

摘要

琥珀酸密螺旋体Cwyk和Canale-Parola 1981具有研究价值,因为这种严格厌氧、无致病性的密螺旋体属成员可氧化碳水化合物,并通过丙酮酸甲酸裂解酶的活性将糖酵解途径与乙酰辅酶A和甲酸的产生相偶联。这一特性使该物种与大多数其他厌氧螺旋体区分开来。琥珀酸密螺旋体6091(T)的基因组是螺旋体科密螺旋体属中第二个完成并发表的模式菌株基因组。这个长度为2,897,425 bp且含有一个质粒的基因组包含2,723个蛋白质编码基因和63个RNA基因,是细菌和古菌基因组百科全书项目的一部分。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88e6/3156407/f68d6fed8ac7/sigs.1984594-f1.jpg

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