Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Skåne University Hospital Malmö, 205 02 Malmö, Sweden.
Curr Diab Rep. 2011 Dec;11(6):552-61. doi: 10.1007/s11892-011-0224-9.
People vary genetically in their susceptibility to the effects of environmental risk factors for many diseases. Genetic variation also underlies the extent to which people respond appropriately to clinical therapies. Defining the basis to the interactions between the genome and the environment may help elucidate the biologic basis to diseases such as type 2 diabetes, as well as help target preventive therapies and treatments. This review examines 1) some of the most current evidence on gene × environment interactions in relation to type 2 diabetes; 2) outlines how the availability of information on gene × environment interactions might help improve the prevention and treatment of type 2 diabetes; and 3) discusses existing and emerging strategies that might enhance our ability to detect and exploit gene × environment interactions in complex disease traits.
人们在对许多疾病的环境风险因素的易感性方面存在基因差异。遗传变异也是人们对临床治疗反应程度的基础。确定基因组与环境之间相互作用的基础可能有助于阐明 2 型糖尿病等疾病的生物学基础，并有助于确定预防治疗和治疗的目标。本综述考察了 1）与 2 型糖尿病相关的基因×环境相互作用的一些最新证据；2）概述了有关基因×环境相互作用的信息的可用性如何帮助改善 2 型糖尿病的预防和治疗；3）讨论了现有的和新兴的策略，这些策略可能增强我们检测和利用复杂疾病特征中基因×环境相互作用的能力。
