Wang Hui, Zhuang Jiaming, Thayumanavan S
Department of Chemistry, University of Massachusetts Amherst, Amherst, Massachusetts 01003.
ACS Macro Lett. 2013 Oct 7;2(10):948-951. doi: 10.1021/mz4004248.
Surface functionalization of nanoparticles and host-guest properties of nanoassemblies are two critical features in the utilization of nanostructures in a variety of applications in materials, chemical, and biological nanotechnology. However, simultaneously incorporating these two features in one nanoparticle design is a rather challenging task. We have developed a simple and versatile nanoparticle platform that addresses this challenge. We have designed and characterized a polymer nanoparticle that provides the ability to encapsulate hydrophobic guest molecules and surface functionalization with a wide range of functional groups. In addition, we have also demonstrated a new and simple approach to tune the size of the nanoparticles.
纳米颗粒的表面功能化以及纳米组装体的主客体性质是纳米结构在材料、化学和生物纳米技术的各种应用中得以利用的两个关键特性。然而，在单一纳米颗粒设计中同时融入这两个特性是一项颇具挑战性的任务。我们开发了一个简单且通用的纳米颗粒平台来应对这一挑战。我们设计并表征了一种聚合物纳米颗粒，它能够封装疏水性客体分子，并能用多种官能团进行表面功能化。此外，我们还展示了一种调节纳米颗粒尺寸的全新且简单的方法。
