用于癌症治疗与成像中联合化疗的活性肿瘤靶向多功能纳米颗粒的最新进展
Recent Developments in Active Tumor Targeted Multifunctional Nanoparticles for Combination Chemotherapy in Cancer Treatment and Imaging.
作者信息
Glasgow Micah D K, Chougule Mahavir B
出版信息
J Biomed Nanotechnol. 2015 Nov;11(11):1859-98. doi: 10.1166/jbn.2015.2145.
Abstract
Nanotechnology and combination therapy are two major fields that show great promise in the treatment of cancer. The delivery of drugs via nanoparticles helps to improve drug's therapeutic effectiveness while reducing adverse side effects associated wifh high dosage by improving their pharmacokinetics. Taking advantage of molecular markers over-expressing on tumor tissues compared to normal cells, an "active" molecular marker targeted approach would be-beneficial for cancer therapy. These actively targeted nanoparticles would increase drug concentration at the tumor site, improving efficacy while further reducing chemo-resistance. The multidisciplinary approach may help to improve the overall efficacy in cancer therapy. This review article summarizes recent developments of targeted multifunctional nanoparticles in the delivery, of various drugs for a combinational chemotherapy approach to cancer treatment and imaging.
摘要
纳米技术和联合疗法是癌症治疗领域中展现出巨大前景的两个主要领域。通过纳米颗粒递送药物有助于提高药物的治疗效果，同时通过改善其药代动力学来减少与高剂量相关的不良副作用。与正常细胞相比，利用肿瘤组织上过度表达的分子标记物，“主动”分子标记物靶向方法将有利于癌症治疗。这些主动靶向纳米颗粒会增加肿瘤部位的药物浓度，提高疗效，同时进一步降低化疗耐药性。多学科方法可能有助于提高癌症治疗的整体疗效。这篇综述文章总结了靶向多功能纳米颗粒在递送各种药物用于联合化疗癌症治疗和成像方面的最新进展。
相似文献
1
Recent Developments in Active Tumor Targeted Multifunctional Nanoparticles for Combination Chemotherapy in Cancer Treatment and Imaging.
J Biomed Nanotechnol. 2015 Nov;11(11):1859-98. doi: 10.1166/jbn.2015.2145.
2
Recent progress in nanotechnology for cancer therapy.
Chin J Cancer. 2010 Sep;29(9):775-80. doi: 10.5732/cjc.010.10075.
3
A targeted nanoplatform co-delivering chemotherapeutic and antiangiogenic drugs as a tool to reverse multidrug resistance in breast cancer.
Acta Biomater. 2018 Jul 15;75:398-412. doi: 10.1016/j.actbio.2018.05.050. Epub 2018 Jun 3.
4
Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy.
Eur J Pharm Biopharm. 2015 Jun;93:52-79. doi: 10.1016/j.ejpb.2015.03.018. Epub 2015 Mar 23.
5
Development of multifunctional nanoparticles for targeted drug delivery and noninvasive imaging of therapeutic effect.
Curr Drug Discov Technol. 2009 Mar;6(1):43-51. doi: 10.2174/157016309787581066.
6
Role of integrated cancer nanomedicine in overcoming drug resistance.
Adv Drug Deliv Rev. 2013 Nov;65(13-14):1784-802. doi: 10.1016/j.addr.2013.07.012. Epub 2013 Jul 21.
7
Multifunctional magneto-polymeric nanohybrids for targeted detection and synergistic therapeutic effects on breast cancer.
Angew Chem Int Ed Engl. 2007;46(46):8836-9. doi: 10.1002/anie.200703554.
8
A light-controllable specific drug delivery nanoplatform for targeted bimodal imaging-guided photothermal/chemo synergistic cancer therapy.
Acta Biomater. 2018 Oct 15;80:308-326. doi: 10.1016/j.actbio.2018.09.024. Epub 2018 Sep 19.
9
Using Peptide Aptamer Targeted Polymers as a Model Nanomedicine for Investigating Drug Distribution in Cancer Nanotheranostics.
Mol Pharm. 2017 Oct 2;14(10):3539-3549. doi: 10.1021/acs.molpharmaceut.7b00560. Epub 2017 Sep 7.
10
Polymer decorated gold nanoparticles in nanomedicine conjugates.
Adv Colloid Interface Sci. 2017 Nov;249:386-399. doi: 10.1016/j.cis.2017.01.007. Epub 2017 Feb 15.
引用本文的文献
1
Cancer-Associated Genetic Aberrations and Precision Medicine.
Int J Med Sci. 2025 Jun 12;22(12):2932-2943. doi: 10.7150/ijms.109506. eCollection 2025.
2
GDF-15 upregulates the SLC7A11/GPX4 signaling axis and promotes mitoxantrone resistance in AML cells.
Eur J Med Res. 2025 Jun 21;30(1):504. doi: 10.1186/s40001-025-02787-x.
3
Fabrication of hydrogel mini-capsules as carrier systems.
Open Res Eur. 2024 Oct 25;3:191. doi: 10.12688/openreseurope.16723.2. eCollection 2023.
4
Updated aspects of alpha-Solanine as a potential anticancer agent: Mechanistic insights and future directions.
Food Sci Nutr. 2024 Aug 29;12(10):7088-7107. doi: 10.1002/fsn3.4221. eCollection 2024 Oct.
5
FeO Nanoparticles That Modulate the Polarisation of Tumor-Associated Macrophages Synergize with Photothermal Therapy and Immunotherapy (PD-1/PD-L1 Inhibitors) to Enhance Anti-Tumor Therapy.
Int J Nanomedicine. 2024 Jul 17;19:7185-7200. doi: 10.2147/IJN.S459400. eCollection 2024.
6
Magnetically modified-mitoxantrone mesoporous organosilica drugs: an emergent multimodal nanochemotherapy for breast cancer.
J Nanobiotechnology. 2024 May 14;22(1):249. doi: 10.1186/s12951-024-02522-4.
7
A comprehensive review on phytochemicals in the treatment and prevention of pancreatic cancer: Focusing on their mechanism of action.
Health Sci Rep. 2024 Apr 29;7(5):e2085. doi: 10.1002/hsr2.2085. eCollection 2024 May.
8
Resveratrol-Based Liposomes Improve Cardiac Remodeling Induced by Isoproterenol Partially by Modulating MEF2, Cytochrome C and S100A1 Expression.
Dose Response. 2024 Apr 18;22(2):15593258241247980. doi: 10.1177/15593258241247980. eCollection 2024 Apr-Jun.
9
Recent Advances in Targeted Drug Delivery Strategy for Enhancing Oncotherapy.
Pharmaceutics. 2023 Aug 29;15(9):2233. doi: 10.3390/pharmaceutics15092233.
10
Multifunctional nanoparticle for cancer therapy.
MedComm (2020). 2023 Jan 11;4(1):e187. doi: 10.1002/mco2.187. eCollection 2023 Feb.
本文引用的文献
1
Aptamer-labeled PLGA nanoparticles for targeting cancer cells.
Cancer Nanotechnol. 2012;3(1-6):1-12. doi: 10.1007/s12645-011-0024-6. Epub 2012 Jan 19.
2
Aptamer-functionalized nanoparticles for drug delivery.
J Biomed Nanotechnol. 2014 Nov;10(11):3189-203. doi: 10.1166/jbn.2014.1839.
3
Multifunctional silica-based nanocomposites for cancer nanotheranostics.
J Biomed Nanotechnol. 2014 Sep;10(9):1784-809. doi: 10.1166/jbn.2014.1886.
4
Nanoparticle enhanced optical imaging and phototherapy of cancer.
J Biomed Nanotechnol. 2014 Sep;10(9):1677-712. doi: 10.1166/jbn.2014.1988.
5
A special issue on reviews in nanomedicine, drug delivery and vaccine development.
J Biomed Nanotechnol. 2014 Sep;10(9):1635-40. doi: 10.1166/jbn.2014.2033.
6
Progress in selection and biomedical applications of aptamers.
J Biomed Nanotechnol. 2014 Oct;10(10):3043-62. doi: 10.1166/jbn.2014.1979.
7
Applications of gold nanoparticles in optical biosensors.
J Biomed Nanotechnol. 2014 Oct;10(10):2700-21. doi: 10.1166/jbn.2014.1987.
8
Fluorescent carbon dots for biolmaging and biosensing applications.
J Biomed Nanotechnol. 2014 Oct;10(10):2677-99. doi: 10.1166/jbn.2014.1881.
9
Nanoparticles for molecular imaging.
J Biomed Nanotechnol. 2014 Oct;10(10):2641-76. doi: 10.1166/jbn.2014.1937.
10
Applications of carbon nanotubes in stem cell research.
J Biomed Nanotechnol. 2014 Oct;10(10):2539-61. doi: 10.1166/jbn.2014.1899.
Zotero 插件